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3key

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Template:STRUCTURE 3key

Contents

Crystal structure of S. cerevisiae Stn1 C-terminal

Template:ABSTRACT PUBMED 20008938

Function

[STN1_YEAST] Has a role in telomere length regulation and telomere end protection. Acts as an inhibitor of telomerase loading through its interaction with CDC13.[1] [2]

About this Structure

3key is a 1 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

  • Sun J, Yu EY, Yang Y, Confer LA, Sun SH, Wan K, Lue NF, Lei M. Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres. Genes Dev. 2009 Dec 15;23(24):2900-14. PMID:20008938 doi:23/24/2900
  1. ↑ Grandin N, Reed SI, Charbonneau M. Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13. Genes Dev. 1997 Feb 15;11(4):512-27. PMID:9042864
  2. ↑ Grandin N, Damon C, Charbonneau M. Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13. EMBO J. 2001 Mar 1;20(5):1173-83. PMID:11230140 doi:10.1093/emboj/20.5.1173

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OCA

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