2dx5
From Proteopedia
(New page: 200px<br /><applet load="2dx5" size="450" color="white" frame="true" align="right" spinBox="true" caption="2dx5, resolution 3.35Å" /> '''The complex structur...) |
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| - | [[Image:2dx5.gif|left|200px]]<br /><applet load="2dx5" size=" | + | [[Image:2dx5.gif|left|200px]]<br /><applet load="2dx5" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2dx5, resolution 3.35Å" /> | caption="2dx5, resolution 3.35Å" /> | ||
'''The complex structure between the mouse EAP45-GLUE domain and ubiquitin'''<br /> | '''The complex structure between the mouse EAP45-GLUE domain and ubiquitin'''<br /> | ||
==Overview== | ==Overview== | ||
| - | ESCRT-II, a complex that sorts ubiquitinated membrane proteins to | + | ESCRT-II, a complex that sorts ubiquitinated membrane proteins to lysosomes, localizes to endosomes through interaction between the Vps36 subunit's GLUE domain and phosphatidylinositides (PIs). In yeast, a ubiquitin (Ub)-interacting NZF domain is inserted in Vps36 GLUE, whereas its mammalian counterpart, Eap45 GLUE, lacks the NZF domain. In the Eap45 GLUE-Ub complex structure, Ub binds far from the proposed PI-binding site of Eap45 GLUE, suggesting their independent binding. |
==About this Structure== | ==About this Structure== | ||
| - | 2DX5 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http:// | + | 2DX5 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DX5 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: ubiquitin]] | [[Category: ubiquitin]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:03:39 2008'' |
Revision as of 15:03, 21 February 2008
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The complex structure between the mouse EAP45-GLUE domain and ubiquitin
Overview
ESCRT-II, a complex that sorts ubiquitinated membrane proteins to lysosomes, localizes to endosomes through interaction between the Vps36 subunit's GLUE domain and phosphatidylinositides (PIs). In yeast, a ubiquitin (Ub)-interacting NZF domain is inserted in Vps36 GLUE, whereas its mammalian counterpart, Eap45 GLUE, lacks the NZF domain. In the Eap45 GLUE-Ub complex structure, Ub binds far from the proposed PI-binding site of Eap45 GLUE, suggesting their independent binding.
About this Structure
2DX5 is a Protein complex structure of sequences from Bos taurus and Mus musculus. Full crystallographic information is available from OCA.
Reference
Structural basis of ubiquitin recognition by mammalian Eap45 GLUE domain., Hirano S, Suzuki N, Slagsvold T, Kawasaki M, Trambaiolo D, Kato R, Stenmark H, Wakatsuki S, Nat Struct Mol Biol. 2006 Nov;13(11):1031-2. Epub 2006 Oct 22. PMID:17057714
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