3kfc

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[[Image:3kfc.png|left|200px]]
 
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{{STRUCTURE_3kfc| PDB=3kfc | SCENE= }}
{{STRUCTURE_3kfc| PDB=3kfc | SCENE= }}
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===Complex Structure of LXR with an agonist===
===Complex Structure of LXR with an agonist===
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{{ABSTRACT_PUBMED_19932617}}
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==Function==
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[[http://www.uniprot.org/uniprot/NR1H2_HUMAN NR1H2_HUMAN]] Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity).
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(as it appears on PubMed at http://www.pubmed.gov), where 19932617 is the PubMed ID number.
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{{ABSTRACT_PUBMED_19932617}}
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==About this Structure==
==About this Structure==
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3KFC is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KFC OCA].
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[[3kfc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KFC OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:19932617</ref><references group="xtra"/>
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<ref group="xtra">PMID:019932617</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bernotas, R C.]]
[[Category: Bernotas, R C.]]
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[[Category: Nuclear receptor]]
[[Category: Nuclear receptor]]
[[Category: Nucleus]]
[[Category: Nucleus]]
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[[Category: Polymorphism]]
 
[[Category: Receptor]]
[[Category: Receptor]]
[[Category: Transcription]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
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[[Category: Zinc]]
 
[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jan 28 14:37:07 2010''
 

Revision as of 02:15, 4 April 2013

Template:STRUCTURE 3kfc

Contents

Complex Structure of LXR with an agonist

Template:ABSTRACT PUBMED 19932617

Function

[NR1H2_HUMAN] Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity).

About this Structure

3kfc is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Bernotas RC, Singhaus RR, Kaufman DH, Travins JM, Ullrich JW, Unwalla R, Quinet E, Evans M, Nambi P, Olland A, Kauppi B, Wilhelmsson A, Goos-Nilsson A, Wrobel J. 4-(3-Aryloxyaryl)quinoline sulfones are potent liver X receptor agonists. Bioorg Med Chem Lett. 2010 Jan 1;20(1):209-12. Epub 2009 Oct 31. PMID:19932617 doi:10.1016/j.bmcl.2009.10.132

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OCA

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