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3kfc
From Proteopedia
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{{STRUCTURE_3kfc| PDB=3kfc | SCENE= }} | {{STRUCTURE_3kfc| PDB=3kfc | SCENE= }} | ||
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===Complex Structure of LXR with an agonist=== | ===Complex Structure of LXR with an agonist=== | ||
| + | {{ABSTRACT_PUBMED_19932617}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/NR1H2_HUMAN NR1H2_HUMAN]] Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity). | |
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==About this Structure== | ==About this Structure== | ||
| - | + | [[3kfc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KFC OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:019932617</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Bernotas, R C.]] | [[Category: Bernotas, R C.]] | ||
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[[Category: Nuclear receptor]] | [[Category: Nuclear receptor]] | ||
[[Category: Nucleus]] | [[Category: Nucleus]] | ||
| - | [[Category: Polymorphism]] | ||
[[Category: Receptor]] | [[Category: Receptor]] | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
[[Category: Transcription regulation]] | [[Category: Transcription regulation]] | ||
| - | [[Category: Zinc]] | ||
[[Category: Zinc-finger]] | [[Category: Zinc-finger]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jan 28 14:37:07 2010'' | ||
Revision as of 02:15, 4 April 2013
Contents |
Complex Structure of LXR with an agonist
Template:ABSTRACT PUBMED 19932617
Function
[NR1H2_HUMAN] Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity).
About this Structure
3kfc is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Bernotas RC, Singhaus RR, Kaufman DH, Travins JM, Ullrich JW, Unwalla R, Quinet E, Evans M, Nambi P, Olland A, Kauppi B, Wilhelmsson A, Goos-Nilsson A, Wrobel J. 4-(3-Aryloxyaryl)quinoline sulfones are potent liver X receptor agonists. Bioorg Med Chem Lett. 2010 Jan 1;20(1):209-12. Epub 2009 Oct 31. PMID:19932617 doi:10.1016/j.bmcl.2009.10.132
