3klt

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Template:STRUCTURE 3klt

Contents

Crystal structure of a vimentin fragment

Template:ABSTRACT PUBMED 20176112

Function

[VIME_HUMAN] Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.[1] Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.[2]

About this Structure

3klt is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Nicolet S, Herrmann H, Aebi U, Strelkov SV. Atomic structure of vimentin coil 2. J Struct Biol. 2010 May;170(2):369-76. Epub 2010 Feb 20. PMID:20176112 doi:10.1016/j.jsb.2010.02.012
  1. ↑ Challa AA, Stefanovic B. A novel role of vimentin filaments: binding and stabilization of collagen mRNAs. Mol Cell Biol. 2011 Sep;31(18):3773-89. doi: 10.1128/MCB.05263-11. Epub 2011 Jul , 11. PMID:21746880 doi:10.1128/MCB.05263-11
  2. ↑ Challa AA, Stefanovic B. A novel role of vimentin filaments: binding and stabilization of collagen mRNAs. Mol Cell Biol. 2011 Sep;31(18):3773-89. doi: 10.1128/MCB.05263-11. Epub 2011 Jul , 11. PMID:21746880 doi:10.1128/MCB.05263-11

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OCA

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