3kee

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Revision as of 02:24, 4 April 2013

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Template:STRUCTURE 3kee

HCV NS3/NS4A complexed with Non-covalent macrocyclic compound TMC435

About this Structure

3kee is a 8 chain structure with sequence from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

• Cummings MD, Lindberg J, Lin TI, de Kock H, Lenz O, Lilja E, Fellander S, Baraznenok V, Nystrom S, Nilsson M, Vrang L, Edlund M, Rosenquist A, Samuelsson B, Raboisson P, Simmen K. Induced-fit binding of the macrocyclic noncovalent inhibitor TMC435 to its HCV NS3/NS4A protease target. Angew Chem Int Ed Engl. 2010 Feb 22;49(9):1652-5. PMID:20166108 doi:10.1002/anie.200906696