2dyn
From Proteopedia
(New page: 200px<br /> <applet load="2dyn" size="450" color="white" frame="true" align="right" spinBox="true" caption="2dyn, resolution 2.30Å" /> '''DYNAMIN (PLECKSTRIN...) |
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| - | [[Image:2dyn.gif|left|200px]]<br /> | + | [[Image:2dyn.gif|left|200px]]<br /><applet load="2dyn" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2dyn" size=" | + | |
caption="2dyn, resolution 2.30Å" /> | caption="2dyn, resolution 2.30Å" /> | ||
'''DYNAMIN (PLECKSTRIN HOMOLOGY DOMAIN) (DYNPH)'''<br /> | '''DYNAMIN (PLECKSTRIN HOMOLOGY DOMAIN) (DYNPH)'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The pleckstrin homology (PH) domain is a conserved module present in many | + | The pleckstrin homology (PH) domain is a conserved module present in many signal transducing and cytoskeletal proteins. Here we report the 2.8 A crystal structure of the PH domain from dynamin. This domain consists of seven beta-strands forming two roughly orthogonal antiparallel beta-sheets terminating with an amphipathic alpha-helix. The structure also reveals a non-covalent dimeric association of the PH domain and a hydrophobic pocket surrounded by a charged rim. The dynamin PH domain structure is discussed in relation to its potential role in mediating interactions between proteins. |
==Disease== | ==Disease== | ||
| - | Known diseases associated with this structure: | + | Known diseases associated with this structure: Encephalopahty, lethal, due to defective mitochondrial peroxisomal fission OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603850 603850]] |
==About this Structure== | ==About this Structure== | ||
| - | 2DYN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 2DYN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DYN OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Timm, D | + | [[Category: Timm, D E.]] |
[[Category: motor protein]] | [[Category: motor protein]] | ||
[[Category: phospholipid binding]] | [[Category: phospholipid binding]] | ||
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[[Category: signal transduction]] | [[Category: signal transduction]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:04:07 2008'' |
Revision as of 15:04, 21 February 2008
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DYNAMIN (PLECKSTRIN HOMOLOGY DOMAIN) (DYNPH)
Contents |
Overview
The pleckstrin homology (PH) domain is a conserved module present in many signal transducing and cytoskeletal proteins. Here we report the 2.8 A crystal structure of the PH domain from dynamin. This domain consists of seven beta-strands forming two roughly orthogonal antiparallel beta-sheets terminating with an amphipathic alpha-helix. The structure also reveals a non-covalent dimeric association of the PH domain and a hydrophobic pocket surrounded by a charged rim. The dynamin PH domain structure is discussed in relation to its potential role in mediating interactions between proteins.
Disease
Known diseases associated with this structure: Encephalopahty, lethal, due to defective mitochondrial peroxisomal fission OMIM:[603850]
About this Structure
2DYN is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the pleckstrin homology domain from dynamin., Timm D, Salim K, Gout I, Guruprasad L, Waterfield M, Blundell T, Nat Struct Biol. 1994 Nov;1(11):782-8. PMID:7634088
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