3k41

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[[Image:3k41.png|left|200px]]
 
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{{STRUCTURE_3k41| PDB=3k41 | SCENE= }}
{{STRUCTURE_3k41| PDB=3k41 | SCENE= }}
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===Crystal structure of sCD-MPR mutant E19Q/K137M bound to Man-6-P===
===Crystal structure of sCD-MPR mutant E19Q/K137M bound to Man-6-P===
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{{ABSTRACT_PUBMED_19928875}}
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==Function==
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[[http://www.uniprot.org/uniprot/MPRD_BOVIN MPRD_BOVIN]] Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.
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{{ABSTRACT_PUBMED_19928875}}
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==About this Structure==
==About this Structure==
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3K41 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K41 OCA].
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[[3k41]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K41 OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:19928875</ref><references group="xtra"/>
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<ref group="xtra">PMID:019928875</ref><references group="xtra"/><references/>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Bohnsack, R N.]]
[[Category: Bohnsack, R N.]]
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[[Category: Membrane]]
[[Category: Membrane]]
[[Category: Phosphoprotein]]
[[Category: Phosphoprotein]]
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[[Category: Protein transport]]
[[Category: Receptor]]
[[Category: Receptor]]
[[Category: Sugar binding]]
[[Category: Sugar binding]]
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[[Category: Sugar binding protein]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
[[Category: Transport]]
[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 20 16:42:26 2010''
 

Revision as of 02:27, 4 April 2013

Template:STRUCTURE 3k41

Contents

Crystal structure of sCD-MPR mutant E19Q/K137M bound to Man-6-P

Template:ABSTRACT PUBMED 19928875

Function

[MPRD_BOVIN] Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.

About this Structure

3k41 is a 2 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

  • Olson LJ, Sun G, Bohnsack RN, Peterson FC, Dahms NM, Kim JJ. Intermonomer interactions are essential for lysosomal enzyme binding by the cation-dependent mannose 6-phosphate receptor. Biochemistry. 2010 Jan 12;49(1):236-46. PMID:19928875 doi:10.1021/bi901725x

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OCA

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