3kem
From Proteopedia
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{{STRUCTURE_3kem| PDB=3kem | SCENE= }} | {{STRUCTURE_3kem| PDB=3kem | SCENE= }} | ||
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===Crystal structure of IspH:IPP complex=== | ===Crystal structure of IspH:IPP complex=== | ||
| + | {{ABSTRACT_PUBMED_020080550}} | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/ISPH_ECOLI ISPH_ECOLI]] Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is also involved in penicillin tolerance and control of the stringent response. Seems to directly or indirectly interact with RelA to maintain it in an inactive form during normal growth.<ref>PMID:19569147</ref> <ref>PMID:20080550</ref> <ref>PMID:22137895</ref> | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3kem]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KEM OCA]. | |
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:020080550</ref><references group="xtra"/><references/> | ||
[[Category: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase]] | [[Category: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase]] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
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[[Category: Groll, M.]] | [[Category: Groll, M.]] | ||
[[Category: Span, I.]] | [[Category: Span, I.]] | ||
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[[Category: Iron]] | [[Category: Iron]] | ||
[[Category: Iron sulfure protein]] | [[Category: Iron sulfure protein]] | ||
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[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
[[Category: Tuberculosis]] | [[Category: Tuberculosis]] | ||
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Revision as of 02:31, 4 April 2013
Contents |
Crystal structure of IspH:IPP complex
Template:ABSTRACT PUBMED 020080550
Function
[ISPH_ECOLI] Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is also involved in penicillin tolerance and control of the stringent response. Seems to directly or indirectly interact with RelA to maintain it in an inactive form during normal growth.[1] [2] [3]
About this Structure
3kem is a 2 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
- Grawert T, Span I, Eisenreich W, Rohdich F, Eppinger J, Bacher A, Groll M. Probing the reaction mechanism of IspH protein by x-ray structure analysis. Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):1077-81. Epub 2009 Dec 28. PMID:20080550
- ↑ Grawert T, Rohdich F, Span I, Bacher A, Eisenreich W, Eppinger J, Groll M. Structure of active IspH enzyme from Escherichia coli provides mechanistic insights into substrate reduction. Angew Chem Int Ed Engl. 2009;48(31):5756-9. PMID:19569147 doi:10.1002/anie.200900548
- ↑ Grawert T, Span I, Eisenreich W, Rohdich F, Eppinger J, Bacher A, Groll M. Probing the reaction mechanism of IspH protein by x-ray structure analysis. Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):1077-81. Epub 2009 Dec 28. PMID:20080550
- ↑ Span I, Grawert T, Bacher A, Eisenreich W, Groll M. Crystal Structures of Mutant IspH Proteins Reveal a Rotation of the Substrate's Hydroxymethyl Group during Catalysis. J Mol Biol. 2011 Nov 23. PMID:22137895 doi:10.1016/j.jmb.2011.11.033
Categories: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase | Escherichia coli | Bacher, A. | Eisenreich, W. | Graewert, T. | Groll, M. | Span, I. | Iron | Iron sulfure protein | Iron-sulfur | Isoprene biosynthesis | Isph | Lytb | Malaria | Metal-binding | Nadp | Non-mevalonic acid pathway | Oxidoreductase | Tuberculosis
