3kmn

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Revision as of 02:40, 4 April 2013

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Template:STRUCTURE 3kmn

Contents 1 Crystal Structure of the Human Apo GST Pi C47S/Y108V Double Mutant 2 Function 3 About this Structure 4 See Also 5 Reference

Crystal Structure of the Human Apo GST Pi C47S/Y108V Double Mutant

Template:ABSTRACT PUBMED 020540076

Function

[GSTP1_HUMAN] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.^[1]

About this Structure

3kmn is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Glutathione S-transferase

Reference

• Quesada-Soriano I, Parker LJ, Primavera A, Wielens J, Holien JK, Casas-Solvas JM, Vargas-Berenguel A, Aguilera AM, Nuccetelli M, Mazzetti AP, Lo Bello M, Parker MW, Garcia-Fuentes L. Diuretic drug binding to human glutathione transferase P1-1: potential role of Cys-101 revealed in the double mutant C47S/Y108V. J Mol Recognit. 2011 Mar-Apr;24(2):220-34. doi: 10.1002/jmr.1040. PMID:20540076 doi:10.1002/jmr.1040

1. ↑ Sun KH, Chang KH, Clawson S, Ghosh S, Mirzaei H, Regnier F, Shah K. Glutathione-S-transferase P1 is a critical regulator of Cdk5 kinase activity. J Neurochem. 2011 Sep;118(5):902-14. doi: 10.1111/j.1471-4159.2011.07343.x. Epub , 2011 Jul 8. PMID:21668448 doi:10.1111/j.1471-4159.2011.07343.x