3k3r
From Proteopedia
| Line 1: | Line 1: | ||
| - | {{Seed}} | ||
| - | [[Image:3k3r.jpg|left|200px]] | ||
| - | |||
| - | <!-- | ||
| - | The line below this paragraph, containing "STRUCTURE_3k3r", creates the "Structure Box" on the page. | ||
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet) | ||
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| - | or leave the SCENE parameter empty for the default display. | ||
| - | --> | ||
{{STRUCTURE_3k3r| PDB=3k3r | SCENE= }} | {{STRUCTURE_3k3r| PDB=3k3r | SCENE= }} | ||
| - | |||
===Unrefined crystal structure of a LexA-DNA complex=== | ===Unrefined crystal structure of a LexA-DNA complex=== | ||
| + | {{ABSTRACT_PUBMED_020703307}} | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/LEXA_ECOLI LEXA_ECOLI]] Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.<ref>PMID:7027255</ref> <ref>PMID:7027256</ref> | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3k3r]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K3R OCA]. | |
| + | |||
| + | ==Reference== | ||
| + | <ref group="xtra">PMID:020703307</ref><references group="xtra"/><references/> | ||
[[Category: Escherichia coli k-12]] | [[Category: Escherichia coli k-12]] | ||
[[Category: Repressor lexA]] | [[Category: Repressor lexA]] | ||
| Line 36: | Line 32: | ||
[[Category: Transcription regulation]] | [[Category: Transcription regulation]] | ||
[[Category: Winged helix-turn-helix]] | [[Category: Winged helix-turn-helix]] | ||
| - | |||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 18 11:42:25 2010'' | ||
Revision as of 02:46, 4 April 2013
Contents |
Unrefined crystal structure of a LexA-DNA complex
Template:ABSTRACT PUBMED 020703307
Function
[LEXA_ECOLI] Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.[1] [2]
About this Structure
3k3r is a 4 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA.
Reference
- Zhang AP, Pigli YZ, Rice PA. Structure of the LexA-DNA complex and implications for SOS box measurement. Nature. 2010 Aug 12;466(7308):883-6. PMID:20703307 doi:10.1038/nature09200
- ↑ Little JW, Mount DW, Yanisch-Perron CR. Purified lexA protein is a repressor of the recA and lexA genes. Proc Natl Acad Sci U S A. 1981 Jul;78(7):4199-203. PMID:7027255
- ↑ Brent R, Ptashne M. Mechanism of action of the lexA gene product. Proc Natl Acad Sci U S A. 1981 Jul;78(7):4204-8. PMID:7027256
Categories: Escherichia coli k-12 | Repressor lexA | Pigli, Y Z. | Rice, P A. | Zhang, A P.P. | Autocatalytic cleavage | Dna damage | Dna repair | Dna replication | Dna-binding | Double helix | Hydrolase | Hydrolase-dna complex | Lexa | Protein-dna complex | Repressor | Sos response | Sos system | Transcription | Transcription regulation | Winged helix-turn-helix
