3kup
From Proteopedia
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{{STRUCTURE_3kup| PDB=3kup | SCENE= }} | {{STRUCTURE_3kup| PDB=3kup | SCENE= }} | ||
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===Crystal Structure of the CBX3 Chromo Shadow Domain=== | ===Crystal Structure of the CBX3 Chromo Shadow Domain=== | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/CBX3_HUMAN CBX3_HUMAN]] Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3kup]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KUP OCA]. | |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith, C H.]] | [[Category: Arrowsmith, C H.]] | ||
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[[Category: Tempel, W.]] | [[Category: Tempel, W.]] | ||
[[Category: Weigelt, J.]] | [[Category: Weigelt, J.]] | ||
| - | [[Category: Acetylation]] | ||
[[Category: Chromatin regulator]] | [[Category: Chromatin regulator]] | ||
[[Category: Chromo shadow domain]] | [[Category: Chromo shadow domain]] | ||
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[[Category: Transcription]] | [[Category: Transcription]] | ||
[[Category: Transcription regulation]] | [[Category: Transcription regulation]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jan 28 14:28:32 2010'' | ||
Revision as of 20:01, 4 April 2013
Crystal Structure of the CBX3 Chromo Shadow Domain
Function
[CBX3_HUMAN] Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
About this Structure
3kup is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Categories: Homo sapiens | Arrowsmith, C H. | Bochkarev, A. | Bountra, C. | Edwards, A M. | Kozieradzki, I. | Li, Y. | Li, Z. | Min, J. | Ouyang, H. | SGC, Structural Genomics Consortium. | Tempel, W. | Weigelt, J. | Chromatin regulator | Chromo shadow domain | Nucleus | Phosphoprotein | Repressor | Sgc | Structural genomics consortium | Transcription | Transcription regulation
