3le8

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[[Image:3le8.jpg|left|200px]]
 
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{{STRUCTURE_3le8| PDB=3le8 | SCENE= }}
{{STRUCTURE_3le8| PDB=3le8 | SCENE= }}
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===Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.70 Angstrom resolution in complex with 2-(2-((benzofuran-2-carboxamido)methyl)-5-methoxy-1H-indol-1-yl)acetic acid===
===Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.70 Angstrom resolution in complex with 2-(2-((benzofuran-2-carboxamido)methyl)-5-methoxy-1H-indol-1-yl)acetic acid===
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{{ABSTRACT_PUBMED_20232910}}
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==Function==
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[[http://www.uniprot.org/uniprot/PANC_MYCTU PANC_MYCTU]] Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.<ref>PMID:11669627</ref>
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{{ABSTRACT_PUBMED_20232910}}
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==About this Structure==
==About this Structure==
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3LE8 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LE8 OCA].
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[[3le8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LE8 OCA].
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==See Also==
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*[[Pantothenate synthetase|Pantothenate synthetase]]
==Reference==
==Reference==
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<ref group="xtra">PMID:20232910</ref><references group="xtra"/>
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<ref group="xtra">PMID:020232910</ref><references group="xtra"/><references/>
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Pantoate--beta-alanine ligase]]
[[Category: Pantoate--beta-alanine ligase]]
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[[Category: Sledz, P.]]
[[Category: Sledz, P.]]
[[Category: Atp-binding]]
[[Category: Atp-binding]]
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[[Category: Cytoplasm]]
 
[[Category: Fragment linking]]
[[Category: Fragment linking]]
[[Category: Fragment-based drug discovery]]
[[Category: Fragment-based drug discovery]]
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[[Category: Nucleotide-binding]]
[[Category: Nucleotide-binding]]
[[Category: Pantothenate biosynthesis]]
[[Category: Pantothenate biosynthesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 14 09:37:48 2010''
 

Revision as of 20:04, 4 April 2013

Template:STRUCTURE 3le8

Contents

Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.70 Angstrom resolution in complex with 2-(2-((benzofuran-2-carboxamido)methyl)-5-methoxy-1H-indol-1-yl)acetic acid

Template:ABSTRACT PUBMED 20232910

Function

[PANC_MYCTU] Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.[1]

About this Structure

3le8 is a 2 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

See Also

Reference

  • Sledz P, Silvestre HL, Hung AW, Ciulli A, Blundell TL, Abell C. Optimization of the interligand overhauser effect for fragment linking: application to inhibitor discovery against Mycobacterium tuberculosis pantothenate synthetase. J Am Chem Soc. 2010 Apr 7;132(13):4544-5. PMID:20232910 doi:10.1021/ja100595u
  1. ↑ Zheng R, Blanchard JS. Steady-state and pre-steady-state kinetic analysis of Mycobacterium tuberculosis pantothenate synthetase. Biochemistry. 2001 Oct 30;40(43):12904-12. PMID:11669627

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