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3le8
From Proteopedia
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Revision as of 20:04, 4 April 2013
Contents |
Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.70 Angstrom resolution in complex with 2-(2-((benzofuran-2-carboxamido)methyl)-5-methoxy-1H-indol-1-yl)acetic acid
Template:ABSTRACT PUBMED 20232910
Function
[PANC_MYCTU] Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.[1]
About this Structure
3le8 is a 2 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.
See Also
Reference
- Sledz P, Silvestre HL, Hung AW, Ciulli A, Blundell TL, Abell C. Optimization of the interligand overhauser effect for fragment linking: application to inhibitor discovery against Mycobacterium tuberculosis pantothenate synthetase. J Am Chem Soc. 2010 Apr 7;132(13):4544-5. PMID:20232910 doi:10.1021/ja100595u
- ↑ Zheng R, Blanchard JS. Steady-state and pre-steady-state kinetic analysis of Mycobacterium tuberculosis pantothenate synthetase. Biochemistry. 2001 Oct 30;40(43):12904-12. PMID:11669627
Categories: Mycobacterium tuberculosis | Pantoate--beta-alanine ligase | Abell, C. | Blundell, T L. | Ciulli, A. | Hung, A W. | Silvestre, H L. | Sledz, P. | Atp-binding | Fragment linking | Fragment-based drug discovery | Iloe | Ligase | Magnesium | Metal-binding | Nucleotide-binding | Pantothenate biosynthesis
