3le8

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Revision as of 20:04, 4 April 2013

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Template:STRUCTURE 3le8

Contents 1 Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.70 Angstrom resolution in complex with 2-(2-((benzofuran-2-carboxamido)methyl)-5-methoxy-1H-indol-1-yl)acetic acid 2 Function 3 About this Structure 4 See Also 5 Reference

Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.70 Angstrom resolution in complex with 2-(2-((benzofuran-2-carboxamido)methyl)-5-methoxy-1H-indol-1-yl)acetic acid

Template:ABSTRACT PUBMED 20232910

Function

[PANC_MYCTU] Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.^[1]

About this Structure

3le8 is a 2 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

See Also

• Pantothenate synthetase

Reference

• Sledz P, Silvestre HL, Hung AW, Ciulli A, Blundell TL, Abell C. Optimization of the interligand overhauser effect for fragment linking: application to inhibitor discovery against Mycobacterium tuberculosis pantothenate synthetase. J Am Chem Soc. 2010 Apr 7;132(13):4544-5. PMID:20232910 doi:10.1021/ja100595u

1. ↑ Zheng R, Blanchard JS. Steady-state and pre-steady-state kinetic analysis of Mycobacterium tuberculosis pantothenate synthetase. Biochemistry. 2001 Oct 30;40(43):12904-12. PMID:11669627