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3ky9

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[[Image:3ky9.png|left|200px]]
 
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{{STRUCTURE_3ky9| PDB=3ky9 | SCENE= }}
{{STRUCTURE_3ky9| PDB=3ky9 | SCENE= }}
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===Autoinhibited Vav1===
===Autoinhibited Vav1===
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{{ABSTRACT_PUBMED_20141838}}
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==Function==
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[[http://www.uniprot.org/uniprot/VAV_HUMAN VAV_HUMAN]] Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.
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{{ABSTRACT_PUBMED_20141838}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:20141838</ref><ref group="xtra">PMID:18488041</ref><ref group="xtra">PMID:16285729</ref><ref group="xtra">PMID:11007481</ref><references group="xtra"/>
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<ref group="xtra">PMID:020141838</ref><ref group="xtra">PMID:018488041</ref><ref group="xtra">PMID:016285729</ref><ref group="xtra">PMID:011007481</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Machius, M.]]
[[Category: Machius, M.]]

Revision as of 20:04, 4 April 2013

Template:STRUCTURE 3ky9

Contents

Autoinhibited Vav1

Template:ABSTRACT PUBMED 20141838

Function

[VAV_HUMAN] Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.

About this Structure

3ky9 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Yu B, Martins IR, Li P, Amarasinghe GK, Umetani J, Fernandez-Zapico ME, Billadeau DD, Machius M, Tomchick DR, Rosen MK. Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1. Cell. 2010 Jan 22;140(2):246-56. PMID:20141838 doi:10.1016/j.cell.2009.12.033
  • Li P, Martins IR, Amarasinghe GK, Rosen MK. Internal dynamics control activation and activity of the autoinhibited Vav DH domain. Nat Struct Mol Biol. 2008 Jun;15(6):613-8. Epub 2008 May 18. PMID:18488041 doi:10.1038/nsmb.1428
  • Amarasinghe GK, Rosen MK. Acidic region tyrosines provide access points for allosteric activation of the autoinhibited Vav1 Dbl homology domain. Biochemistry. 2005 Nov 22;44(46):15257-68. PMID:16285729 doi:10.1021/bi051126h
  • Aghazadeh B, Lowry WE, Huang XY, Rosen MK. Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation. Cell. 2000 Sep 1;102(5):625-33. PMID:11007481

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