3ky9

(Difference between revisions)

Revision as of 20:04, 4 April 2013

[VAV_HUMAN] Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.

3ky9 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Yu B, Martins IR, Li P, Amarasinghe GK, Umetani J, Fernandez-Zapico ME, Billadeau DD, Machius M, Tomchick DR, Rosen MK. Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1. Cell. 2010 Jan 22;140(2):246-56. PMID:20141838 doi:10.1016/j.cell.2009.12.033
Li P, Martins IR, Amarasinghe GK, Rosen MK. Internal dynamics control activation and activity of the autoinhibited Vav DH domain. Nat Struct Mol Biol. 2008 Jun;15(6):613-8. Epub 2008 May 18. PMID:18488041 doi:10.1038/nsmb.1428
Amarasinghe GK, Rosen MK. Acidic region tyrosines provide access points for allosteric activation of the autoinhibited Vav1 Dbl homology domain. Biochemistry. 2005 Nov 22;44(46):15257-68. PMID:16285729 doi:10.1021/bi051126h
Aghazadeh B, Lowry WE, Huang XY, Rosen MK. Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation. Cell. 2000 Sep 1;102(5):625-33. PMID:11007481

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-[[Image:3ky9.png|left|200px]]
-<!--
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 {{STRUCTURE_3ky9|  PDB=3ky9  |  SCENE=  }}
 ===Autoinhibited Vav1===
+{{ABSTRACT_PUBMED_20141838}}
+==Function==
-<!--
+[[http://www.uniprot.org/uniprot/VAV_HUMAN VAV_HUMAN]] Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.
-The line below this paragraph, {{ABSTRACT_PUBMED_20141838}}, adds the Publication Abstract to the page
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-{{ABSTRACT_PUBMED_20141838}}
 ==About this Structure==
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 ==Reference==
-<ref group="xtra">PMID:20141838</ref><ref group="xtra">PMID:18488041</ref><ref group="xtra">PMID:16285729</ref><ref group="xtra">PMID:11007481</ref><references group="xtra"/>
+<ref group="xtra">PMID:020141838</ref><ref group="xtra">PMID:018488041</ref><ref group="xtra">PMID:016285729</ref><ref group="xtra">PMID:011007481</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Machius, M.]]