3lcn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3lcn.png|left|200px]]
 
- 
-
<!--
 
-
The line below this paragraph, containing "STRUCTURE_3lcn", creates the "Structure Box" on the page.
 
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
 
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
 
-
or leave the SCENE parameter empty for the default display.
 
-
-->
 
{{STRUCTURE_3lcn| PDB=3lcn | SCENE= }}
{{STRUCTURE_3lcn| PDB=3lcn | SCENE= }}
- 
===Nab2:Gfd1 complex===
===Nab2:Gfd1 complex===
 +
{{ABSTRACT_PUBMED_20463024}}
-
 
+
==Function==
-
<!--
+
[[http://www.uniprot.org/uniprot/NAB2_YEAST NAB2_YEAST]] This essential protein binds to polyadenylated RNA and single-stranded DNA. It may be involved not only in RNA processing but also in transcription regulation. Believed to associate directly with nascent RNA polymerase II transcripts and remain associated during subsequent nuclear RNA processing reactions. [[http://www.uniprot.org/uniprot/GFD1_YEAST GFD1_YEAST]] High-copy suppressor of mutant alleles of ATP-dependent RNA helicase DBP5, which is involved in mRNA export from the nucleus. It may also play an important role in a late stage of NAB2-mRNA export.<ref>PMID:10610322</ref> <ref>PMID:10523319</ref> <ref>PMID:15208322</ref>
-
The line below this paragraph, {{ABSTRACT_PUBMED_20463024}}, adds the Publication Abstract to the page
+
-
(as it appears on PubMed at http://www.pubmed.gov), where 20463024 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_20463024}}
+
==About this Structure==
==About this Structure==
-
3LCN is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LCN OCA].
+
[[3lcn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LCN OCA].
==Reference==
==Reference==
-
<ref group="xtra">PMID:20463024</ref><references group="xtra"/>
+
<ref group="xtra">PMID:020463024</ref><references group="xtra"/><references/>
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Stewart, M.]]
[[Category: Stewart, M.]]
Line 39: Line 26:
[[Category: Transport]]
[[Category: Transport]]
[[Category: Zinc-finger]]
[[Category: Zinc-finger]]
- 
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 6 05:39:00 2010''
 

Revision as of 20:06, 4 April 2013

Template:STRUCTURE 3lcn

Contents

Nab2:Gfd1 complex

Template:ABSTRACT PUBMED 20463024

Function

[NAB2_YEAST] This essential protein binds to polyadenylated RNA and single-stranded DNA. It may be involved not only in RNA processing but also in transcription regulation. Believed to associate directly with nascent RNA polymerase II transcripts and remain associated during subsequent nuclear RNA processing reactions. [GFD1_YEAST] High-copy suppressor of mutant alleles of ATP-dependent RNA helicase DBP5, which is involved in mRNA export from the nucleus. It may also play an important role in a late stage of NAB2-mRNA export.[1] [2] [3]

About this Structure

3lcn is a 4 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

  • Zheng C, Fasken MB, Marshall NJ, Brockmann C, Rubinson ME, Wente SR, Corbett AH, Stewart M. Structural basis for the function of the Saccharomyces cerevisiae Gfd1 protein in mRNA nuclear export. J Biol Chem. 2010 Jul 2;285(27):20704-15. Epub 2010 May 12. PMID:20463024 doi:10.1074/jbc.M110.107276
  1. ↑ Strahm Y, Fahrenkrog B, Zenklusen D, Rychner E, Kantor J, Rosbach M, Stutz F. The RNA export factor Gle1p is located on the cytoplasmic fibrils of the NPC and physically interacts with the FG-nucleoporin Rip1p, the DEAD-box protein Rat8p/Dbp5p and a new protein Ymr 255p. EMBO J. 1999 Oct 15;18(20):5761-77. PMID:10610322 doi:10.1093/emboj/18.20.5761
  2. ↑ Hodge CA, Colot HV, Stafford P, Cole CN. Rat8p/Dbp5p is a shuttling transport factor that interacts with Rat7p/Nup159p and Gle1p and suppresses the mRNA export defect of xpo1-1 cells. EMBO J. 1999 Oct 15;18(20):5778-88. PMID:10523319 doi:10.1093/emboj/18.20.5778
  3. ↑ Suntharalingam M, Alcazar-Roman AR, Wente SR. Nuclear export of the yeast mRNA-binding protein Nab2 is linked to a direct interaction with Gfd1 and to Gle1 function. J Biol Chem. 2004 Aug 20;279(34):35384-91. Epub 2004 Jun 18. PMID:15208322 doi:10.1074/jbc.M402044200

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3lcn"
Personal tools