3ld1
From Proteopedia
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{{STRUCTURE_3ld1| PDB=3ld1 | SCENE= }} | {{STRUCTURE_3ld1| PDB=3ld1 | SCENE= }} | ||
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===Crystal Structure of IBV Nsp2a=== | ===Crystal Structure of IBV Nsp2a=== | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/R1A_IBVM R1A_IBVM]] The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. Activity of PL-PRO is dependent on zinc (By similarity). The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function (By similarity). The peptide p16 might be involved in the EGF signaling pathway (By similarity). Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter (By similarity). Nsp9 is a ssRNA-binding protein (By similarity). | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Xu, Y.]] | [[Category: Xu, Y.]] | ||
[[Category: Yang, A.]] | [[Category: Yang, A.]] | ||
| + | [[Category: Globular like]] | ||
| + | [[Category: Host cytoplasm]] | ||
| + | [[Category: Host membrane]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Membrane]] | ||
| + | [[Category: Metal-binding]] | ||
| + | [[Category: Protease]] | ||
| + | [[Category: Rna-binding]] | ||
| + | [[Category: Thiol protease]] | ||
| + | [[Category: Transmembrane]] | ||
| + | [[Category: Zinc-finger]] | ||
Revision as of 20:08, 4 April 2013
Crystal Structure of IBV Nsp2a
Function
[R1A_IBVM] The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. Activity of PL-PRO is dependent on zinc (By similarity). The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Also contains an ADP-ribose-1-phosphate (ADRP)-binding function (By similarity). The peptide p16 might be involved in the EGF signaling pathway (By similarity). Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter (By similarity). Nsp9 is a ssRNA-binding protein (By similarity).
About this Structure
3ld1 is a 1 chain structure with sequence from Viruses. Full crystallographic information is available from OCA.
Categories: Viruses | Bartlam, M. | Chen, C. | Cong, L. | Fu, J. | Rao, Z. | Tang, H. | Wei, L. | Xu, Y. | Yang, A. | Globular like | Host cytoplasm | Host membrane | Hydrolase | Membrane | Metal-binding | Protease | Rna-binding | Thiol protease | Transmembrane | Zinc-finger
