3l1p
From Proteopedia
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{{STRUCTURE_3l1p| PDB=3l1p | SCENE= }} | {{STRUCTURE_3l1p| PDB=3l1p | SCENE= }} | ||
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===POU protein:DNA complex=== | ===POU protein:DNA complex=== | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/PO5F1_MOUSE PO5F1_MOUSE]] Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.<ref>PMID:17496161</ref> <ref>PMID:17525163</ref> | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3l1p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L1P OCA]. | |
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| + | ==Reference== | ||
| + | <references group="xtra"/><references/> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Groves, M R.]] | [[Category: Groves, M R.]] | ||
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[[Category: Transcription factor dna complex]] | [[Category: Transcription factor dna complex]] | ||
[[Category: Transcription-dna complex]] | [[Category: Transcription-dna complex]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 15 08:40:47 2010'' | ||
Revision as of 20:14, 4 April 2013
Contents |
POU protein:DNA complex
Function
[PO5F1_MOUSE] Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.[1] [2]
About this Structure
3l1p is a 4 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
- ↑ Zhang Z, Liao B, Xu M, Jin Y. Post-translational modification of POU domain transcription factor Oct-4 by SUMO-1. FASEB J. 2007 Oct;21(12):3042-51. Epub 2007 May 11. PMID:17496161 doi:fj.06-6914com
- ↑ Wei F, Scholer HR, Atchison ML. Sumoylation of Oct4 enhances its stability, DNA binding, and transactivation. J Biol Chem. 2007 Jul 20;282(29):21551-60. Epub 2007 May 24. PMID:17525163 doi:M611041200
