3l91
From Proteopedia
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{{STRUCTURE_3l91| PDB=3l91 | SCENE= }} | {{STRUCTURE_3l91| PDB=3l91 | SCENE= }} | ||
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===Structure of Pseudomonas aerugionsa PvdQ bound to octanoate=== | ===Structure of Pseudomonas aerugionsa PvdQ bound to octanoate=== | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/PVDQ_PSEAE PVDQ_PSEAE]] Catalyzes the deacylation of acyl-homoserine lactone (AHL or acyl-HSL), releasing homoserine lactone (HSL) and the corresponding fatty acid. Possesses a specificity for the degradation of long-chain acyl-HSLs (side chains of 11 to 14 carbons in length). Degrades 3-oxo-C12-HSL, one of the two main AHL signal molecules of P.aeruginosa, and thereby functions as a quorum quencher, inhibiting the las quorum-sensing system. Therefore, may enable P.aeruginosa to modulate its own quorum-sensing-dependent pathogenic potential. Also appears to be required for pyoverdin biosynthesis.<ref>PMID:16495538</ref> <ref>PMID:14532048</ref> <ref>PMID:12686626</ref> | ||
==About this Structure== | ==About this Structure== | ||
[[3l91]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L91 OCA]. | [[3l91]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L91 OCA]. | ||
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| + | ==Reference== | ||
| + | <references group="xtra"/><references/> | ||
[[Category: Acyl-homoserine-lactone acylase]] | [[Category: Acyl-homoserine-lactone acylase]] | ||
[[Category: Pseudomonas aeruginosa]] | [[Category: Pseudomonas aeruginosa]] | ||
[[Category: Drake, E J.]] | [[Category: Drake, E J.]] | ||
[[Category: Gulick, A M.]] | [[Category: Gulick, A M.]] | ||
| + | [[Category: Acylase]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Ntn hydrolase]] | ||
| + | [[Category: Pvdq]] | ||
| + | [[Category: Pyoverdine]] | ||
| + | [[Category: Quorum sensing]] | ||
| + | [[Category: Zymogen]] | ||
Revision as of 20:15, 4 April 2013
Contents |
Structure of Pseudomonas aerugionsa PvdQ bound to octanoate
Function
[PVDQ_PSEAE] Catalyzes the deacylation of acyl-homoserine lactone (AHL or acyl-HSL), releasing homoserine lactone (HSL) and the corresponding fatty acid. Possesses a specificity for the degradation of long-chain acyl-HSLs (side chains of 11 to 14 carbons in length). Degrades 3-oxo-C12-HSL, one of the two main AHL signal molecules of P.aeruginosa, and thereby functions as a quorum quencher, inhibiting the las quorum-sensing system. Therefore, may enable P.aeruginosa to modulate its own quorum-sensing-dependent pathogenic potential. Also appears to be required for pyoverdin biosynthesis.[1] [2] [3]
About this Structure
3l91 is a 2 chain structure with sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.
Reference
- ↑ Sio CF, Otten LG, Cool RH, Diggle SP, Braun PG, Bos R, Daykin M, Camara M, Williams P, Quax WJ. Quorum quenching by an N-acyl-homoserine lactone acylase from Pseudomonas aeruginosa PAO1. Infect Immun. 2006 Mar;74(3):1673-82. PMID:16495538 doi:74/3/1673
- ↑ Huang JJ, Han JI, Zhang LH, Leadbetter JR. Utilization of acyl-homoserine lactone quorum signals for growth by a soil pseudomonad and Pseudomonas aeruginosa PAO1. Appl Environ Microbiol. 2003 Oct;69(10):5941-9. PMID:14532048
- ↑ Lamont IL, Martin LW. Identification and characterization of novel pyoverdine synthesis genes in Pseudomonas aeruginosa. Microbiology. 2003 Apr;149(Pt 4):833-42. PMID:12686626
