3l6b

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[[Image:3l6b.png|left|200px]]
 
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{{STRUCTURE_3l6b| PDB=3l6b | SCENE= }}
{{STRUCTURE_3l6b| PDB=3l6b | SCENE= }}
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===X-ray crystal structure of human serine racemase in complex with malonate a potent inhibitor===
===X-ray crystal structure of human serine racemase in complex with malonate a potent inhibitor===
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{{ABSTRACT_PUBMED_20106978}}
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==Function==
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[[http://www.uniprot.org/uniprot/SRR_HUMAN SRR_HUMAN]] Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.<ref>PMID:11054547</ref> <ref>PMID:20106978</ref>
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{{ABSTRACT_PUBMED_20106978}}
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==About this Structure==
==About this Structure==
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3L6B is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L6B OCA].
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[[3l6b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L6B OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:20106978</ref><references group="xtra"/>
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<ref group="xtra">PMID:020106978</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Serine racemase]]
[[Category: Serine racemase]]
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[[Category: Pyridoxal phosphate]]
[[Category: Pyridoxal phosphate]]
[[Category: Serine racemase]]
[[Category: Serine racemase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 12 10:27:09 2010''
 

Revision as of 20:20, 4 April 2013

Template:STRUCTURE 3l6b

Contents

X-ray crystal structure of human serine racemase in complex with malonate a potent inhibitor

Template:ABSTRACT PUBMED 20106978

Function

[SRR_HUMAN] Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.[1] [2]

About this Structure

3l6b is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Smith MA, Mack V, Ebneth A, Moraes I, Felicetti B, Wood M, Schonfeld D, Mather O, Cesura A, Barker J. The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding. J Biol Chem. 2010 Apr 23;285(17):12873-81. Epub 2010 Jan 27. PMID:20106978 doi:10.1074/jbc.M109.050062
  1. ↑ De Miranda J, Santoro A, Engelender S, Wolosker H. Human serine racemase: moleular cloning, genomic organization and functional analysis. Gene. 2000 Oct 3;256(1-2):183-8. PMID:11054547
  2. ↑ Smith MA, Mack V, Ebneth A, Moraes I, Felicetti B, Wood M, Schonfeld D, Mather O, Cesura A, Barker J. The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding. J Biol Chem. 2010 Apr 23;285(17):12873-81. Epub 2010 Jan 27. PMID:20106978 doi:10.1074/jbc.M109.050062

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