3lgd
From Proteopedia
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{{STRUCTURE_3lgd| PDB=3lgd | SCENE= }} | {{STRUCTURE_3lgd| PDB=3lgd | SCENE= }} | ||
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===Crystal structure of human adenosine deaminase growth factor, adenosine deaminase type 2 (ADA2)=== | ===Crystal structure of human adenosine deaminase growth factor, adenosine deaminase type 2 (ADA2)=== | ||
| + | {{ABSTRACT_PUBMED_20147294}} | ||
| + | ==Disease== | ||
| + | [[http://www.uniprot.org/uniprot/CECR1_HUMAN CECR1_HUMAN]] Cat-eye syndrome. | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/CECR1_HUMAN CECR1_HUMAN]] Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity.<ref>PMID:20453107</ref> <ref>PMID:20147294</ref> | |
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==About this Structure== | ==About this Structure== | ||
| - | + | [[3lgd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LGD OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:020147294</ref><references group="xtra"/><references/> |
[[Category: Adenosine deaminase]] | [[Category: Adenosine deaminase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
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[[Category: Secreted]] | [[Category: Secreted]] | ||
[[Category: Tim barrel]] | [[Category: Tim barrel]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 20 08:59:02 2010'' | ||
Revision as of 20:24, 4 April 2013
Contents |
Crystal structure of human adenosine deaminase growth factor, adenosine deaminase type 2 (ADA2)
Template:ABSTRACT PUBMED 20147294
Disease
[CECR1_HUMAN] Cat-eye syndrome.
Function
[CECR1_HUMAN] Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity.[1] [2]
About this Structure
3lgd is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Zavialov AV, Yu X, Spillmann D, Lauvau G, Zavialov AV. Structural basis for the growth factor activity of human adenosine deaminase ADA2. J Biol Chem. 2010 Apr 16;285(16):12367-77. Epub 2010 Feb 9. PMID:20147294 doi:10.1074/jbc.M109.083527
- ↑ Zavialov AV, Gracia E, Glaichenhaus N, Franco R, Zavialov AV, Lauvau G. Human adenosine deaminase 2 induces differentiation of monocytes into macrophages and stimulates proliferation of T helper cells and macrophages. J Leukoc Biol. 2010 Aug;88(2):279-90. doi: 10.1189/jlb.1109764. Epub 2010 May 7. PMID:20453107 doi:10.1189/jlb.1109764
- ↑ Zavialov AV, Yu X, Spillmann D, Lauvau G, Zavialov AV. Structural basis for the growth factor activity of human adenosine deaminase ADA2. J Biol Chem. 2010 Apr 16;285(16):12367-77. Epub 2010 Feb 9. PMID:20147294 doi:10.1074/jbc.M109.083527
