3kvc

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3kvc.png|left|200px]]
 
- 
-
<!--
 
-
The line below this paragraph, containing "STRUCTURE_3kvc", creates the "Structure Box" on the page.
 
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
 
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
 
-
or leave the SCENE parameter empty for the default display.
 
-
-->
 
{{STRUCTURE_3kvc| PDB=3kvc | SCENE= }}
{{STRUCTURE_3kvc| PDB=3kvc | SCENE= }}
- 
===Crystal structure of bovine RPE65 at 1.9 angstrom resolution===
===Crystal structure of bovine RPE65 at 1.9 angstrom resolution===
 +
{{ABSTRACT_PUBMED_20100834}}
-
 
+
==Function==
-
<!--
+
[[http://www.uniprot.org/uniprot/RPE65_BOVIN RPE65_BOVIN]] Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of the expression levels and membrane association.<ref>PMID:16096063</ref> <ref>PMID:19805034</ref> <ref>PMID:20100834</ref>
-
The line below this paragraph, {{ABSTRACT_PUBMED_20100834}}, adds the Publication Abstract to the page
+
-
(as it appears on PubMed at http://www.pubmed.gov), where 20100834 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_20100834}}
+
==About this Structure==
==About this Structure==
-
3KVC is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KVC OCA].
+
[[3kvc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KVC OCA].
==Reference==
==Reference==
-
<ref group="xtra">PMID:20100834</ref><references group="xtra"/>
+
<ref group="xtra">PMID:020100834</ref><references group="xtra"/><references/>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Golczak, M.]]
[[Category: Golczak, M.]]
Line 30: Line 17:
[[Category: Palczewski, K.]]
[[Category: Palczewski, K.]]
[[Category: 7-bladed beta-propeller]]
[[Category: 7-bladed beta-propeller]]
-
[[Category: Acetylation]]
 
[[Category: Cell membrane]]
[[Category: Cell membrane]]
-
[[Category: Cytoplasm]]
 
[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Iron]]
[[Category: Iron]]
Line 45: Line 30:
[[Category: Sensory transduction]]
[[Category: Sensory transduction]]
[[Category: Vision]]
[[Category: Vision]]
- 
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 12 10:36:00 2010''
 

Revision as of 20:31, 4 April 2013

Template:STRUCTURE 3kvc

Contents

Crystal structure of bovine RPE65 at 1.9 angstrom resolution

Template:ABSTRACT PUBMED 20100834

Function

[RPE65_BOVIN] Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of the expression levels and membrane association.[1] [2] [3]

About this Structure

3kvc is a 2 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

  • Golczak M, Kiser PD, Lodowski DT, Maeda A, Palczewski K. Importance of membrane structural integrity for RPE65 retinoid isomerization activity. J Biol Chem. 2010 Mar 26;285(13):9667-82. Epub 2010 Jan 25. PMID:20100834 doi:10.1074/jbc.M109.063941
  1. ↑ Jin M, Li S, Moghrabi WN, Sun H, Travis GH. Rpe65 is the retinoid isomerase in bovine retinal pigment epithelium. Cell. 2005 Aug 12;122(3):449-59. PMID:16096063 doi:10.1016/j.cell.2005.06.042
  2. ↑ Kiser PD, Golczak M, Lodowski DT, Chance MR, Palczewski K. Crystal structure of native RPE65, the retinoid isomerase of the visual cycle. Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17325-30. Epub 2009 Oct 5. PMID:19805034
  3. ↑ Golczak M, Kiser PD, Lodowski DT, Maeda A, Palczewski K. Importance of membrane structural integrity for RPE65 retinoid isomerization activity. J Biol Chem. 2010 Mar 26;285(13):9667-82. Epub 2010 Jan 25. PMID:20100834 doi:10.1074/jbc.M109.063941

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3kvc"
Personal tools