3lh5

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[[Image:3lh5.png|left|200px]]
 
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{{STRUCTURE_3lh5| PDB=3lh5 | SCENE= }}
{{STRUCTURE_3lh5| PDB=3lh5 | SCENE= }}
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===Crystal Structure of the SH3-Guanylate kinase core domain of ZO-1===
===Crystal Structure of the SH3-Guanylate kinase core domain of ZO-1===
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{{ABSTRACT_PUBMED_20200156}}
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==Function==
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[[http://www.uniprot.org/uniprot/ZO1_HUMAN ZO1_HUMAN]] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.<ref>PMID:21240187</ref>
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{{ABSTRACT_PUBMED_20200156}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:20200156</ref><references group="xtra"/>
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<ref group="xtra">PMID:020200156</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Lavie, A.]]
[[Category: Lavie, A.]]
[[Category: Lye, M F.]]
[[Category: Lye, M F.]]
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[[Category: Cell junction]]
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[[Category: Cell membrane]]
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[[Category: Intramolecular fold]]
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[[Category: Membrane]]
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[[Category: Phosphoprotein]]
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[[Category: Protein binding]]
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[[Category: Sh3 domain]]
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[[Category: Sh3-guanylate kinase]]
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[[Category: Tight junction]]
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[[Category: Zo-1]]

Revision as of 20:48, 4 April 2013

Template:STRUCTURE 3lh5

Contents

Crystal Structure of the SH3-Guanylate kinase core domain of ZO-1

Template:ABSTRACT PUBMED 20200156

Function

[ZO1_HUMAN] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.[1]

About this Structure

3lh5 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Lye MF, Fanning AS, Su Y, Anderson JM, Lavie A. Insights into regulated ligand binding sites from the structure of ZO-1 Src homology 3-guanylate kinase module. J Biol Chem. 2010 Apr 30;285(18):13907-17. Epub 2010 Mar 3. PMID:20200156 doi:10.1074/jbc.M109.093674
  1. ↑ Huo L, Wen W, Wang R, Kam C, Xia J, Feng W, Zhang M. Cdc42-dependent formation of the ZO-1/MRCKbeta complex at the leading edge controls cell migration. EMBO J. 2011 Feb 16;30(4):665-78. Epub 2011 Jan 14. PMID:21240187 doi:10.1038/emboj.2010.353

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