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3lh5
From Proteopedia
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{{STRUCTURE_3lh5| PDB=3lh5 | SCENE= }} | {{STRUCTURE_3lh5| PDB=3lh5 | SCENE= }} | ||
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===Crystal Structure of the SH3-Guanylate kinase core domain of ZO-1=== | ===Crystal Structure of the SH3-Guanylate kinase core domain of ZO-1=== | ||
| + | {{ABSTRACT_PUBMED_20200156}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/ZO1_HUMAN ZO1_HUMAN]] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.<ref>PMID:21240187</ref> | |
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:020200156</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Lavie, A.]] | [[Category: Lavie, A.]] | ||
[[Category: Lye, M F.]] | [[Category: Lye, M F.]] | ||
| + | [[Category: Cell junction]] | ||
| + | [[Category: Cell membrane]] | ||
| + | [[Category: Intramolecular fold]] | ||
| + | [[Category: Membrane]] | ||
| + | [[Category: Phosphoprotein]] | ||
| + | [[Category: Protein binding]] | ||
| + | [[Category: Sh3 domain]] | ||
| + | [[Category: Sh3-guanylate kinase]] | ||
| + | [[Category: Tight junction]] | ||
| + | [[Category: Zo-1]] | ||
Revision as of 20:48, 4 April 2013
Contents |
Crystal Structure of the SH3-Guanylate kinase core domain of ZO-1
Template:ABSTRACT PUBMED 20200156
Function
[ZO1_HUMAN] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.[1]
About this Structure
3lh5 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Lye MF, Fanning AS, Su Y, Anderson JM, Lavie A. Insights into regulated ligand binding sites from the structure of ZO-1 Src homology 3-guanylate kinase module. J Biol Chem. 2010 Apr 30;285(18):13907-17. Epub 2010 Mar 3. PMID:20200156 doi:10.1074/jbc.M109.093674
- ↑ Huo L, Wen W, Wang R, Kam C, Xia J, Feng W, Zhang M. Cdc42-dependent formation of the ZO-1/MRCKbeta complex at the leading edge controls cell migration. EMBO J. 2011 Feb 16;30(4):665-78. Epub 2011 Jan 14. PMID:21240187 doi:10.1038/emboj.2010.353
