2pqk
From Proteopedia
(Difference between revisions)
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| - | [[Image:2pqk.png|left|200px]] | ||
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{{STRUCTURE_2pqk| PDB=2pqk | SCENE= }} | {{STRUCTURE_2pqk| PDB=2pqk | SCENE= }} | ||
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===X-ray crystal structure of human Mcl-1 in complex with Bim BH3=== | ===X-ray crystal structure of human Mcl-1 in complex with Bim BH3=== | ||
| + | {{ABSTRACT_PUBMED_20066663}} | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref> | ||
==About this Structure== | ==About this Structure== | ||
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==See Also== | ==See Also== | ||
*[[Bcl-2|Bcl-2]] | *[[Bcl-2|Bcl-2]] | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:020066663</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Bare, E.]] | [[Category: Bare, E.]] | ||
Revision as of 21:43, 10 April 2013
Contents |
X-ray crystal structure of human Mcl-1 in complex with Bim BH3
Template:ABSTRACT PUBMED 20066663
Function
[MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.[1]
About this Structure
2pqk is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Fire E, Gulla SV, Grant RA, Keating AE. Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes. Protein Sci. 2010 Jan 11. PMID:20066663 doi:10.1002/pro.329
- ↑ Bingle CD, Craig RW, Swales BM, Singleton V, Zhou P, Whyte MK. Exon skipping in Mcl-1 results in a bcl-2 homology domain 3 only gene product that promotes cell death. J Biol Chem. 2000 Jul 21;275(29):22136-46. PMID:10766760 doi:10.1074/jbc.M909572199
