4e68

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===Unphosphorylated STAT3B core protein binding to dsDNA===
===Unphosphorylated STAT3B core protein binding to dsDNA===
{{ABSTRACT_PUBMED_23434585}}
{{ABSTRACT_PUBMED_23434585}}
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==Function==
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[[http://www.uniprot.org/uniprot/STAT3_MOUSE STAT3_MOUSE]] Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. STAT3B interacts with the N-terminal part of JUN to activate such promoters in a cooperative way.<ref>PMID:11294897</ref>
==About this Structure==
==About this Structure==
[[4e68]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E68 OCA].
[[4e68]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E68 OCA].
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==Reference==
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<references group="xtra"/><references/>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Collie, G W.]]
[[Category: Collie, G W.]]

Revision as of 21:44, 10 April 2013

Template:STRUCTURE 4e68

Contents

Unphosphorylated STAT3B core protein binding to dsDNA

Template:ABSTRACT PUBMED 23434585

Function

[STAT3_MOUSE] Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. STAT3B interacts with the N-terminal part of JUN to activate such promoters in a cooperative way.[1]

About this Structure

4e68 is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  1. ↑ Hart KC, Robertson SC, Donoghue DJ. Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation. Mol Biol Cell. 2001 Apr;12(4):931-42. PMID:11294897

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