4ed5
From Proteopedia
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{{STRUCTURE_4ed5| PDB=4ed5 | SCENE= }} | {{STRUCTURE_4ed5| PDB=4ed5 | SCENE= }} | ||
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===Crystal structure of the two N-terminal RRM domains of HuR complexed with RNA=== | ===Crystal structure of the two N-terminal RRM domains of HuR complexed with RNA=== | ||
| + | {{ABSTRACT_PUBMED_23519412}} | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/ELAV1_HUMAN ELAV1_HUMAN]] Involved in 3'-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro.<ref>PMID:19029303</ref> | ||
==About this Structure== | ==About this Structure== | ||
[[4ed5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ED5 OCA]. | [[4ed5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ED5 OCA]. | ||
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| + | ==Reference== | ||
| + | <references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Li, X.]] | [[Category: Li, X.]] | ||
Revision as of 21:44, 10 April 2013
Contents |
Crystal structure of the two N-terminal RRM domains of HuR complexed with RNA
Template:ABSTRACT PUBMED 23519412
Function
[ELAV1_HUMAN] Involved in 3'-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro.[1]
About this Structure
4ed5 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- ↑ Weidensdorfer D, Stohr N, Baude A, Lederer M, Kohn M, Schierhorn A, Buchmeier S, Wahle E, Huttelmaier S. Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs. RNA. 2009 Jan;15(1):104-15. doi: 10.1261/rna.1175909. Epub 2008 Nov 24. PMID:19029303 doi:10.1261/rna.1175909
Categories: Homo sapiens | Li, X. | Liu, Q. | Niu, L. | Teng, M. | Wang, H. | Zeng, F. | Nucleus | Rna binding | Rna binding protein-rna complex | Rrm
