4i06

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'''Unreleased structure'''
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{{STRUCTURE_4i06| PDB=4i06 | SCENE= }}
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===Crystal structure of human Arginase-2 complexed with inhibitor 14===
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{{ABSTRACT_PUBMED_23472952}}
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The entry 4i06 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/ARGI2_HUMAN ARGI2_HUMAN]] May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.
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Authors: Cousido-Siah, A., Mitschler, A., Ruiz, F.X., Whitehouse, D.L., Golebiowski, A., Ji, M., Zhang, M., Beckett ,P., Sheeler, R., Andreoli, M., Conway, B., Mahboubi, K., Schroeter, H., Van Zandt, M.C., Podjarny, A.
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==About this Structure==
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[[4i06]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I06 OCA].
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Description: Crystal structure of human Arginase-2 complexed with inhibitor 14
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[[Category: Arginase]]
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[[Category: Homo sapiens]]
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[[Category: Andreoli, M.]]
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[[Category: Beckett ,P.]]
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[[Category: Conway, B.]]
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[[Category: Cousido-Siah, A.]]
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[[Category: Golebiowski, A.]]
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[[Category: Ji, M.]]
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[[Category: Mahboubi, K.]]
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[[Category: Mitschler, A.]]
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[[Category: Podjarny, A.]]
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[[Category: Ruiz, F X.]]
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[[Category: Schroeter, H.]]
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[[Category: Sheeler, R.]]
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[[Category: Whitehouse, D L.]]
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[[Category: Zandt, M C.Van.]]
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[[Category: Zhang, M.]]
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[[Category: Alpha/beta fold]]
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[[Category: Arginine metabolism]]
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[[Category: Hydrolase]]
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[[Category: Manganese]]
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[[Category: Metalloenzyme]]
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[[Category: Mitochondrion]]

Revision as of 21:48, 10 April 2013

Template:STRUCTURE 4i06

Crystal structure of human Arginase-2 complexed with inhibitor 14

Template:ABSTRACT PUBMED 23472952

Function

[ARGI2_HUMAN] May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.

About this Structure

4i06 is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Proteopedia Page Contributors and Editors (what is this?)

OCA

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