4hww

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'''Unreleased structure'''
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{{STRUCTURE_4hww| PDB=4hww | SCENE= }}
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===Crystal structure of human Arginase-1 complexed with inhibitor 9===
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{{ABSTRACT_PUBMED_23472952}}
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The entry 4hww is ON HOLD until Paper Publication
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==Disease==
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[[http://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN]] Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:[http://omim.org/entry/207800 207800]]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.<ref>PMID:1463019</ref> <ref>PMID:7649538</ref>
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Authors: Cousido-Siah, A., Mitschler, A., Ruiz, F.X., Whitehouse, D.L., Golebiowski, A., Ji, M., Zhang, M., Beckett , P., Sheeler, R., Andreoli, M., Conway, B., Mahboubi, K., Schroeter, H., Van Zandt, M.C., Podjarny, A.
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==About this Structure==
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[[4hww]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HWW OCA].
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Description: Crystal structure of human Arginase-1 complexed with inhibitor 9
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Arginase]]
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[[Category: Homo sapiens]]
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[[Category: Andreoli, M.]]
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[[Category: Beckett , P.]]
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[[Category: Conway, B.]]
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[[Category: Cousido-Siah, A.]]
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[[Category: Golebiowski, A.]]
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[[Category: Ji, M.]]
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[[Category: Mahboubi, K.]]
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[[Category: Mitschler, A.]]
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[[Category: Podjarny, A.]]
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[[Category: Ruiz, F X.]]
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[[Category: Schroeter, H.]]
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[[Category: Sheeler, R.]]
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[[Category: Whitehouse, D L.]]
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[[Category: Zandt, M C.Van.]]
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[[Category: Zhang, M.]]
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[[Category: Alpha/beta fold]]
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[[Category: Arginine metabolism]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Manganese]]
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[[Category: Metalloenzyme]]

Revision as of 21:50, 10 April 2013

Template:STRUCTURE 4hww

Contents

Crystal structure of human Arginase-1 complexed with inhibitor 9

Template:ABSTRACT PUBMED 23472952

Disease

[ARGI1_HUMAN] Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:207800]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.[1] [2]

About this Structure

4hww is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Uchino T, Haraguchi Y, Aparicio JM, Mizutani N, Higashikawa M, Naitoh H, Mori M, Matsuda I. Three novel mutations in the liver-type arginase gene in three unrelated Japanese patients with argininemia. Am J Hum Genet. 1992 Dec;51(6):1406-12. PMID:1463019
  2. ↑ Uchino T, Snyderman SE, Lambert M, Qureshi IA, Shapira SK, Sansaricq C, Smit LM, Jakobs C, Matsuda I. Molecular basis of phenotypic variation in patients with argininemia. Hum Genet. 1995 Sep;96(3):255-60. PMID:7649538

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OCA

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