This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3j2u
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:3j2u.jpg|left|200px]] | ||
| - | |||
{{STRUCTURE_3j2u| PDB=3j2u | SCENE= }} | {{STRUCTURE_3j2u| PDB=3j2u | SCENE= }} | ||
| - | |||
===Kinesin-13 KLP10A HD in complex with CS-tubulin and a microtubule=== | ===Kinesin-13 KLP10A HD in complex with CS-tubulin and a microtubule=== | ||
| - | |||
{{ABSTRACT_PUBMED_23434508}} | {{ABSTRACT_PUBMED_23434508}} | ||
| + | |||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/KI10A_DROME KI10A_DROME]] Required during anaphase to drive sister chromatid separation to promote flux by actively depolymerizing kinetochore microtubules at their pole-associated minus ends, thereby moving chromatids through a "poleward flux".<ref>PMID:14681690</ref> [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). [[http://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. | ||
==About this Structure== | ==About this Structure== | ||
[[3j2u]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Gekko_coi Gekko coi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J2U OCA]. | [[3j2u]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Gekko_coi Gekko coi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J2U OCA]. | ||
| + | |||
| + | ==Reference== | ||
| + | <references group="xtra"/><references/> | ||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Gekko coi]] | [[Category: Gekko coi]] | ||
Revision as of 21:57, 10 April 2013
Contents |
Kinesin-13 KLP10A HD in complex with CS-tubulin and a microtubule
Template:ABSTRACT PUBMED 23434508
Function
[KI10A_DROME] Required during anaphase to drive sister chromatid separation to promote flux by actively depolymerizing kinetochore microtubules at their pole-associated minus ends, thereby moving chromatids through a "poleward flux".[1] [TBB2B_BOVIN] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). [TBA1B_BOVIN] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
About this Structure
3j2u is a 5 chain structure with sequence from Bos taurus and Gekko coi. Full crystallographic information is available from OCA.
Reference
- ↑ Rogers GC, Rogers SL, Schwimmer TA, Ems-McClung SC, Walczak CE, Vale RD, Scholey JM, Sharp DJ. Two mitotic kinesins cooperate to drive sister chromatid separation during anaphase. Nature. 2004 Jan 22;427(6972):364-70. Epub 2003 Dec 14. PMID:14681690 doi:10.1038/nature02256
Categories: Bos taurus | Gekko coi | Asenjo, A B. | Chatterjee, C. | DePaoli, V. | Diaz-Avalos, R. | Rice, W J. | Silvestry, M. | Sosa, H. | Tan, D. | Depolymerase | Depolymerization | Kinesin | Kinesin-13 | Kinesin13 | Kini | Microtubule | Motor protein | Tubulin
