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3jxt

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{{STRUCTURE_3jxt| PDB=3jxt | SCENE= }}
{{STRUCTURE_3jxt| PDB=3jxt | SCENE= }}
===Crystal structure of the third PDZ domain of SAP-102 in complex with a fluorogenic peptide-based ligand===
===Crystal structure of the third PDZ domain of SAP-102 in complex with a fluorogenic peptide-based ligand===
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{{ABSTRACT_PUBMED_23480637}}
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==Disease==
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[[http://www.uniprot.org/uniprot/CCG2_MOUSE CCG2_MOUSE]] Note=Defects in Cacng2 cause the stargazer (stg) phenotype. Stg mice have spike-wave seizures characteristic of absence epilepsy, with accompanying defects in the cerebellum and inner ear.
==Function==
==Function==
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[[http://www.uniprot.org/uniprot/DLG3_RAT DLG3_RAT]] Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling (By similarity).
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[[http://www.uniprot.org/uniprot/DLG3_RAT DLG3_RAT]] Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling (By similarity). [[http://www.uniprot.org/uniprot/CCG2_MOUSE CCG2_MOUSE]] Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).
==About this Structure==
==About this Structure==

Revision as of 21:59, 10 April 2013

Template:STRUCTURE 3jxt

Contents

Crystal structure of the third PDZ domain of SAP-102 in complex with a fluorogenic peptide-based ligand

Template:ABSTRACT PUBMED 23480637

Disease

[CCG2_MOUSE] Note=Defects in Cacng2 cause the stargazer (stg) phenotype. Stg mice have spike-wave seizures characteristic of absence epilepsy, with accompanying defects in the cerebellum and inner ear.

Function

[DLG3_RAT] Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling (By similarity). [CCG2_MOUSE] Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).

About this Structure

3jxt is a 4 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

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