4h2s

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[[Image:4h2s.jpg|left|200px]]
 
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{{STRUCTURE_4h2s| PDB=4h2s | SCENE= }}
{{STRUCTURE_4h2s| PDB=4h2s | SCENE= }}
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===Crystal structure of Bradyrhizobium japonicum glycine:[carrier protein] ligase complexed with cognate carrier protein and AMP===
===Crystal structure of Bradyrhizobium japonicum glycine:[carrier protein] ligase complexed with cognate carrier protein and AMP===
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{{ABSTRACT_PUBMED_23541895}}
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{{ABSTRACT_PUBMED_20663952}}
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==Function==
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[[http://www.uniprot.org/uniprot/AACL1_BRAJA AACL1_BRAJA]] Catalyzes the ATP-dependent activation of L-glycine and its transfer to the phosphopantetheine prosthetic group covalently attached to the vicinal carrier protein bsr0959 of yet unknown function. May participate in nonribosomal peptide synthesis or related processes. L-alanine is a poor substrate whereas L-serine or D-amino acids are not substrates for ATP-dependent activation. Does not display tRNA aminoacylation activity. [[http://www.uniprot.org/uniprot/AACP1_BRAJA AACP1_BRAJA]] Aminoacyl carrier protein. Can be charged with L-glycine via the formation of a thioester bond between the amino acid and the 4'-phosphopantetheinyl prosthetic group, catalyzed by the bll0957 ligase.
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:020663952</ref><references group="xtra"/>
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<ref group="xtra">PMID:020663952</ref><references group="xtra"/><references/>
[[Category: Bradyrhizobium japonicum usda 110]]
[[Category: Bradyrhizobium japonicum usda 110]]
[[Category: Ivic, N.]]
[[Category: Ivic, N.]]

Revision as of 22:00, 10 April 2013

Template:STRUCTURE 4h2s

Contents

Crystal structure of Bradyrhizobium japonicum glycine:[carrier protein] ligase complexed with cognate carrier protein and AMP

Template:ABSTRACT PUBMED 23541895

Function

[AACL1_BRAJA] Catalyzes the ATP-dependent activation of L-glycine and its transfer to the phosphopantetheine prosthetic group covalently attached to the vicinal carrier protein bsr0959 of yet unknown function. May participate in nonribosomal peptide synthesis or related processes. L-alanine is a poor substrate whereas L-serine or D-amino acids are not substrates for ATP-dependent activation. Does not display tRNA aminoacylation activity. [AACP1_BRAJA] Aminoacyl carrier protein. Can be charged with L-glycine via the formation of a thioester bond between the amino acid and the 4'-phosphopantetheinyl prosthetic group, catalyzed by the bll0957 ligase.

About this Structure

4h2s is a 4 chain structure with sequence from Bradyrhizobium japonicum usda 110. Full crystallographic information is available from OCA.

Reference

  • Mocibob M, Ivic N, Bilokapic S, Maier T, Luic M, Ban N, Weygand-Durasevic I. Homologs of aminoacyl-tRNA synthetases acylate carrier proteins and provide a link between ribosomal and nonribosomal peptide synthesis. Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14585-90. Epub 2010 Jul 27. PMID:20663952 doi:10.1073/pnas.1007470107

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OCA

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