3vdo

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'''Unreleased structure'''
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{{STRUCTURE_3vdo| PDB=3vdo | SCENE= }}
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===Structure of extra-cytoplasmic function(ECF) sigma factor SigK in complex with its negative regulator RskA from Mycobacterium tuberculosis===
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The entry 3vdo is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/SIGK_MYCTU SIGK_MYCTU]] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Sigma-K controls genes such as mpt70 and mpt83. [[http://www.uniprot.org/uniprot/RSKA_MYCTU RSKA_MYCTU]] Represses SigK, the extracytoplasmic function (ECF) sigma factor K, by binding to it and inhibiting its activity. This leads to a decreased expression of SigK-regulated genes, such as mpt70 and mpt83.
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Authors: Shukla, J.K., Gopal, B.
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==About this Structure==
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[[3vdo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VDO OCA].
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Description: Structure of extra-cytoplasmic function(ECF) sigma factor SigK in complex with its negative regulator RskA from Mycobacterium tuberculosis
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Gopal, B.]]
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[[Category: Shukla, J K.]]
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[[Category: Dna]]
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[[Category: Dna binding protein-protein binding complex]]
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[[Category: Ecf sigma factor]]
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[[Category: Promoter dna binding]]
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[[Category: Recognition and transcription initiation]]

Revision as of 22:37, 10 April 2013

Template:STRUCTURE 3vdo

Structure of extra-cytoplasmic function(ECF) sigma factor SigK in complex with its negative regulator RskA from Mycobacterium tuberculosis

Function

[SIGK_MYCTU] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Sigma-K controls genes such as mpt70 and mpt83. [RSKA_MYCTU] Represses SigK, the extracytoplasmic function (ECF) sigma factor K, by binding to it and inhibiting its activity. This leads to a decreased expression of SigK-regulated genes, such as mpt70 and mpt83.

About this Structure

3vdo is a 2 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

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OCA

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