3zon

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3zon" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_3zon| PDB=3zon | SCENE= }}
 +
===Human TYK2 pseudokinase domain bound to a kinase inhibitor===
-
The entry 3zon is ON HOLD
+
==Disease==
 +
[[http://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN]] Mendelian susceptibility to mycobacterial diseases;Autosomal recessive hyper IgE syndrome. Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:[http://omim.org/entry/611521 611521]]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.
-
Authors: Elkins, J.M., Wang, J., Krojer, T., Savitsky, P., Chalk, R., Daga, N., Salah, E., Berridge, G., Picaud, S., von Delft, F., Bountra, C., Edwards, A., Knapp, S.
+
==Function==
 +
[[http://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN]] Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.<ref>PMID:7526154</ref>
-
Description: Human TYK2 pseudokinase domain bound to a kinase inhibitor
+
==About this Structure==
 +
[[3zon]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZON OCA].
 +
 
 +
==Reference==
 +
<references group="xtra"/><references/>
 +
[[Category: Homo sapiens]]
 +
[[Category: Berridge, G.]]
 +
[[Category: Bountra, C.]]
 +
[[Category: Chalk, R.]]
 +
[[Category: Daga, N.]]
 +
[[Category: Delft, F von.]]
 +
[[Category: Edwards, A.]]
 +
[[Category: Elkins, J M.]]
 +
[[Category: Knapp, S.]]
 +
[[Category: Krojer, T.]]
 +
[[Category: Picaud, S.]]
 +
[[Category: Salah, E.]]
 +
[[Category: Savitsky, P.]]
 +
[[Category: Wang, J.]]
 +
[[Category: Jak]]
 +
[[Category: Transferase]]

Revision as of 22:39, 10 April 2013

Template:STRUCTURE 3zon

Contents

Human TYK2 pseudokinase domain bound to a kinase inhibitor

Disease

[TYK2_HUMAN] Mendelian susceptibility to mycobacterial diseases;Autosomal recessive hyper IgE syndrome. Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:611521]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.

Function

[TYK2_HUMAN] Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.[1]

About this Structure

3zon is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Colamonici O, Yan H, Domanski P, Handa R, Smalley D, Mullersman J, Witte M, Krishnan K, Krolewski J. Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase. Mol Cell Biol. 1994 Dec;14(12):8133-42. PMID:7526154

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3zon"
Personal tools