4bdq

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "4bdq" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4bdq| PDB=4bdq | SCENE= }}
 +
===Crystal structure of the GluK2 R775A LBD dimer in complex with glutamate===
-
The entry 4bdq is ON HOLD
+
==Function==
 +
[[http://www.uniprot.org/uniprot/GRIK2_RAT GRIK2_RAT]] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2 (By similarity).<ref>PMID:17486098</ref> <ref>PMID:17115050</ref>
-
Authors: Nayeem, N., Mayans, O., Green, T.
+
==About this Structure==
 +
[[4bdq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BDQ OCA].
-
Description: Crystal structure of the GluK2 R775A LBD dimer in complex with glutamate
+
==Reference==
 +
<references group="xtra"/><references/>
 +
[[Category: Rattus norvegicus]]
 +
[[Category: Green, T.]]
 +
[[Category: Mayans, O.]]
 +
[[Category: Nayeem, N.]]
 +
[[Category: Ionotropic glutamate receptor]]
 +
[[Category: Kainate receptor]]
 +
[[Category: Metal transport]]

Revision as of 22:39, 10 April 2013

Template:STRUCTURE 4bdq

Contents

Crystal structure of the GluK2 R775A LBD dimer in complex with glutamate

Function

[GRIK2_RAT] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2 (By similarity).[1] [2]

About this Structure

4bdq is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  1. ↑ Martin S, Nishimune A, Mellor JR, Henley JM. SUMOylation regulates kainate-receptor-mediated synaptic transmission. Nature. 2007 May 17;447(7142):321-5. Epub 2007 May 7. PMID:17486098 doi:nature05736
  2. ↑ Weston MC, Schuck P, Ghosal A, Rosenmund C, Mayer ML. Conformational restriction blocks glutamate receptor desensitization. Nat Struct Mol Biol. 2006 Dec;13(12):1120-7. Epub 2006 Nov 19. PMID:17115050 doi:http://dx.doi.org/10.1038/nsmb1178

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4bdq"
Personal tools