4ht2

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'''Unreleased structure'''
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{{STRUCTURE_4ht2| PDB=4ht2 | SCENE= }}
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===Crystal structure of human carbonic anhydrase isozyme XII with the inhibitor.===
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{{ABSTRACT_PUBMED_23394791}}
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The entry 4ht2 is ON HOLD until Paper Publication
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==Disease==
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[[http://www.uniprot.org/uniprot/CAH12_HUMAN CAH12_HUMAN]] Defects in CA12 are the cause of hyperchlorhidrosis isolated (HCHLH) [MIM:[http://omim.org/entry/143860 143860]]. HCHLH is a disorder characterized by excessive sweating and increased sweat chloride levels. Affected individuals suffer from episodes of hyponatremic dehydration and report increased amounts of visible salt precipitates in sweat.<ref>PMID:21035102</ref>
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Authors: Smirnov, A., Manakova, E., Grazulis, S.
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==Function==
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[[http://www.uniprot.org/uniprot/CAH12_HUMAN CAH12_HUMAN]] Reversible hydration of carbon dioxide.
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Description: Crystal structure of human carbonic anhydrase isozyme XII with the inhibitor.
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==About this Structure==
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[[4ht2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HT2 OCA].
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Carbonate dehydratase]]
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[[Category: Homo sapiens]]
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[[Category: Grazulis, S.]]
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[[Category: Manakova, E.]]
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[[Category: Smirnov, A.]]
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[[Category: Benzenesulfonamide]]
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[[Category: Carbon-oxygen lyase activity]]
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[[Category: Carbonate dehydratase activity]]
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[[Category: Carbonic anhydrase]]
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[[Category: Catalytic activity]]
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[[Category: Drug design]]
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[[Category: Lyase-lyase inhibitor complex]]
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[[Category: Membrane]]
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[[Category: Metal-binding]]

Revision as of 22:45, 10 April 2013

Template:STRUCTURE 4ht2

Contents

Crystal structure of human carbonic anhydrase isozyme XII with the inhibitor.

Template:ABSTRACT PUBMED 23394791

Disease

[CAH12_HUMAN] Defects in CA12 are the cause of hyperchlorhidrosis isolated (HCHLH) [MIM:143860]. HCHLH is a disorder characterized by excessive sweating and increased sweat chloride levels. Affected individuals suffer from episodes of hyponatremic dehydration and report increased amounts of visible salt precipitates in sweat.[1]

Function

[CAH12_HUMAN] Reversible hydration of carbon dioxide.

About this Structure

4ht2 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Feldshtein M, Elkrinawi S, Yerushalmi B, Marcus B, Vullo D, Romi H, Ofir R, Landau D, Sivan S, Supuran CT, Birk OS. Hyperchlorhidrosis caused by homozygous mutation in CA12, encoding carbonic anhydrase XII. Am J Hum Genet. 2010 Nov 12;87(5):713-20. doi: 10.1016/j.ajhg.2010.10.008. Epub, 2010 Oct 28. PMID:21035102 doi:10.1016/j.ajhg.2010.10.008

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OCA

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