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3mf1
From Proteopedia
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{{STRUCTURE_3mf1| PDB=3mf1 | SCENE= }} | {{STRUCTURE_3mf1| PDB=3mf1 | SCENE= }} | ||
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===Crystal structure of class II aaRS homologue (Bll0957) complexed with an analogue of glycyl adenylate=== | ===Crystal structure of class II aaRS homologue (Bll0957) complexed with an analogue of glycyl adenylate=== | ||
| + | {{ABSTRACT_PUBMED_20663952}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/Q89VT8_BRAJA Q89VT8_BRAJA]] Catalyzes the ATP-dependent activation of L-glycine and its transfer to the phosphopantetheine prosthetic group covalently attached to the vicinal carrier protein bsr0959 of yet unknown function. May participate in nonribosomal peptide synthesis or related processes. L-alanine is a poor substrate whereas L-serine or D-amino acids are not substrates for ATP-dependent activation. Does not display tRNA aminoacylation activity. | |
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:020663952</ref><ref group="xtra">PMID:016675947</ref><references group="xtra"/><references/> |
[[Category: Bradyrhizobium japonicum]] | [[Category: Bradyrhizobium japonicum]] | ||
[[Category: Ban, N.]] | [[Category: Ban, N.]] | ||
Revision as of 23:02, 10 April 2013
Contents |
Crystal structure of class II aaRS homologue (Bll0957) complexed with an analogue of glycyl adenylate
Template:ABSTRACT PUBMED 20663952
Function
[Q89VT8_BRAJA] Catalyzes the ATP-dependent activation of L-glycine and its transfer to the phosphopantetheine prosthetic group covalently attached to the vicinal carrier protein bsr0959 of yet unknown function. May participate in nonribosomal peptide synthesis or related processes. L-alanine is a poor substrate whereas L-serine or D-amino acids are not substrates for ATP-dependent activation. Does not display tRNA aminoacylation activity.
About this Structure
3mf1 is a 2 chain structure with sequence from Bradyrhizobium japonicum. Full crystallographic information is available from OCA.
Reference
- Mocibob M, Ivic N, Bilokapic S, Maier T, Luic M, Ban N, Weygand-Durasevic I. Homologs of aminoacyl-tRNA synthetases acylate carrier proteins and provide a link between ribosomal and nonribosomal peptide synthesis. Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14585-90. Epub 2010 Jul 27. PMID:20663952 doi:10.1073/pnas.1007470107
- Bilokapic S, Maier T, Ahel D, Gruic-Sovulj I, Soll D, Weygand-Durasevic I, Ban N. Structure of the unusual seryl-tRNA synthetase reveals a distinct zinc-dependent mode of substrate recognition. EMBO J. 2006 Jun 7;25(11):2498-509. Epub 2006 May 4. PMID:16675947
