3m66

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Template:STRUCTURE 3m66

Contents

Crystal structure of human Mitochondrial Transcription Termination Factor 3

Template:ABSTRACT PUBMED 20430012

Function

[MTER1_HUMAN] Binds promoter DNA and regulates initiation of transcription. Required for normal mitochondrial transcription, and for normal assembly of mitochondrial respiratory complexes. Required for normal mitochondrial function (By similarity).[1]

About this Structure

3m66 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Spahr H, Samuelsson T, Hallberg BM, Gustafsson CM. Structure of mitochondrial transcription termination factor 3 reveals a novel nucleic acid-binding domain. Biochem Biophys Res Commun. 2010 Jul 2;397(3):386-90. Epub 2010 Apr 27. PMID:20430012 doi:10.1016/j.bbrc.2010.04.130
  1. ↑ Park CB, Asin-Cayuela J, Camara Y, Shi Y, Pellegrini M, Gaspari M, Wibom R, Hultenby K, Erdjument-Bromage H, Tempst P, Falkenberg M, Gustafsson CM, Larsson NG. MTERF3 is a negative regulator of mammalian mtDNA transcription. Cell. 2007 Jul 27;130(2):273-85. PMID:17662942 doi:10.1016/j.cell.2007.05.046

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OCA

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