3m3q

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{{STRUCTURE_3m3q| PDB=3m3q | SCENE= }}
{{STRUCTURE_3m3q| PDB=3m3q | SCENE= }}
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===Crystal Structure of Agrocybe aegerita lectin AAL complexed with Ganglosides GM1 pentasaccharide===
===Crystal Structure of Agrocybe aegerita lectin AAL complexed with Ganglosides GM1 pentasaccharide===
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{{ABSTRACT_PUBMED_20530247}}
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==Function==
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[[http://www.uniprot.org/uniprot/ATLE_AGRAE ATLE_AGRAE]] Anti-tumor lectin with DNase activity. Inhibits the growth of several tumor cell lines in vitro. Induces lymphocyte infiltration and necrosis of tumor cells in a mouse tumor model. Induces apoptosis in HeLa cells.<ref>PMID:12757412</ref>
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{{ABSTRACT_PUBMED_20530247}}
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==About this Structure==
==About this Structure==
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3M3Q is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Agrocybe_aegerita Agrocybe aegerita]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M3Q OCA].
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[[3m3q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Agrocybe_aegerita Agrocybe aegerita]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M3Q OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:20530247</ref><references group="xtra"/>
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<ref group="xtra">PMID:020530247</ref><references group="xtra"/><references/>
[[Category: Agrocybe aegerita]]
[[Category: Agrocybe aegerita]]
[[Category: Feng, L.]]
[[Category: Feng, L.]]
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[[Category: Lectin]]
[[Category: Lectin]]
[[Category: Nuclease]]
[[Category: Nuclease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 1 11:30:43 2010''
 

Revision as of 23:07, 10 April 2013

Template:STRUCTURE 3m3q

Contents

Crystal Structure of Agrocybe aegerita lectin AAL complexed with Ganglosides GM1 pentasaccharide

Template:ABSTRACT PUBMED 20530247

Function

[ATLE_AGRAE] Anti-tumor lectin with DNase activity. Inhibits the growth of several tumor cell lines in vitro. Induces lymphocyte infiltration and necrosis of tumor cells in a mouse tumor model. Induces apoptosis in HeLa cells.[1]

About this Structure

3m3q is a 2 chain structure with sequence from Agrocybe aegerita. Full crystallographic information is available from OCA.

Reference

  • Feng L, Sun H, Zhang Y, Li DF, Wang DC. Structural insights into the recognition mechanism between an antitumor galectin AAL and the Thomsen-Friedenreich antigen. FASEB J. 2010 Oct;24(10):3861-8. Epub 2010 Jun 7. PMID:20530247 doi:10.1096/fj.10-159111
  1. ↑ Zhao C, Sun H, Tong X, Qi Y. An antitumour lectin from the edible mushroom Agrocybe aegerita. Biochem J. 2003 Sep 1;374(Pt 2):321-7. PMID:12757412 doi:10.1042/BJ20030300

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