3m9q

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Revision as of 23:16, 10 April 2013

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Template:STRUCTURE 3m9q

Contents 1 Drosophila MSL3 chromodomain 2 Function 3 About this Structure 4 Reference

Drosophila MSL3 chromodomain

Template:ABSTRACT PUBMED 20657587

Function

[MSL3_DROME] The MSL proteins are essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation). Mle, msl-1 and msl-3 are colocalized on the X chromosome. Each of the MSL proteins requires all the other MSLs for wild-type X-chromosome binding.^[1]

About this Structure

3m9q is a 2 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

• Kim D, Blus BJ, Chandra V, Huang P, Rastinejad F, Khorasanizadeh S. Corecognition of DNA and a methylated histone tail by the MSL3 chromodomain. Nat Struct Mol Biol. 2010 Aug;17(8):1027-9. Epub 2010 Jul 25. PMID:20657587 doi:10.1038/nsmb.1856

1. ↑ Gorman M, Franke A, Baker BS. Molecular characterization of the male-specific lethal-3 gene and investigations of the regulation of dosage compensation in Drosophila. Development. 1995 Feb;121(2):463-75. PMID:7768187