3mca
From Proteopedia
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===Structure of the Dom34-Hbs1 Complex and implications for its role in No-Go decay=== | ===Structure of the Dom34-Hbs1 Complex and implications for its role in No-Go decay=== | ||
| + | {{ABSTRACT_PUBMED_20890290}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/HBS1_SCHPO HBS1_SCHPO]] Involved in protein translation. Together with dom34, may function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs (By similarity).[UniProtKB:P32769] [[http://www.uniprot.org/uniprot/DOM34_SCHPO DOM34_SCHPO]] Involved in protein translation. Together with hbs1, may function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. The complex formed by dom34 and hbs1 has ribonuclease activity towards double-stranded RNA substrates, but does not cleave single-stranded RNA. Acts as endonuclease; has no exonuclease activity. Increases the affinity of hbs1 for GTP, but nor for GDP. Promotes G1 progression and differentiation and is involved in mitotic and meiotic cell divisions (By similarity).[UniProtKB:P33309] | |
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==About this Structure== | ==About this Structure== | ||
| - | + | [[3mca]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MCA OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:020890290</ref><references group="xtra"/><references/> |
[[Category: Schizosaccharomyces pombe]] | [[Category: Schizosaccharomyces pombe]] | ||
[[Category: Chen, L.]] | [[Category: Chen, L.]] | ||
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[[Category: Translation regulation]] | [[Category: Translation regulation]] | ||
[[Category: Translation regulation-hydrolase complex]] | [[Category: Translation regulation-hydrolase complex]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 20 06:12:57 2010'' | ||
Revision as of 23:18, 10 April 2013
Contents |
Structure of the Dom34-Hbs1 Complex and implications for its role in No-Go decay
Template:ABSTRACT PUBMED 20890290
Function
[HBS1_SCHPO] Involved in protein translation. Together with dom34, may function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs (By similarity).[UniProtKB:P32769] [DOM34_SCHPO] Involved in protein translation. Together with hbs1, may function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. The complex formed by dom34 and hbs1 has ribonuclease activity towards double-stranded RNA substrates, but does not cleave single-stranded RNA. Acts as endonuclease; has no exonuclease activity. Increases the affinity of hbs1 for GTP, but nor for GDP. Promotes G1 progression and differentiation and is involved in mitotic and meiotic cell divisions (By similarity).[UniProtKB:P33309]
About this Structure
3mca is a 2 chain structure with sequence from Schizosaccharomyces pombe. Full crystallographic information is available from OCA.
Reference
- Chen L, Muhlrad D, Hauryliuk V, Cheng Z, Lim MK, Shyp V, Parker R, Song H. Structure of the Dom34-Hbs1 complex and implications for no-go decay. Nat Struct Mol Biol. 2010 Oct;17(10):1233-40. Epub 2010 Oct 3. PMID:20890290 doi:10.1038/nsmb.1922
