3m5b

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[[Image:3m5b.png|left|200px]]
 
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{{STRUCTURE_3m5b| PDB=3m5b | SCENE= }}
{{STRUCTURE_3m5b| PDB=3m5b | SCENE= }}
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===Crystal structure of the BTB domain from FAZF/ZBTB32===
===Crystal structure of the BTB domain from FAZF/ZBTB32===
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{{ABSTRACT_PUBMED_20493880}}
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==Function==
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[[http://www.uniprot.org/uniprot/ZBT32_HUMAN ZBT32_HUMAN]] DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells (By similarity).<ref>PMID:10572087</ref>
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{{ABSTRACT_PUBMED_20493880}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:20493880</ref><references group="xtra"/>
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<ref group="xtra">PMID:020493880</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Pomroy, N C.]]
[[Category: Pomroy, N C.]]

Revision as of 23:19, 10 April 2013

Template:STRUCTURE 3m5b

Contents

Crystal structure of the BTB domain from FAZF/ZBTB32

Template:ABSTRACT PUBMED 20493880

Function

[ZBT32_HUMAN] DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells (By similarity).[1]

About this Structure

3m5b is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Stogios PJ, Cuesta-Seijo JA, Chen L, Pomroy NC, Prive GG. Insights into strand exchange in BTB domain dimers from the crystal structures of FAZF and Miz1. J Mol Biol. 2010 Jul 30;400(5):983-97. Epub 2010 May 21. PMID:20493880 doi:10.1016/j.jmb.2010.05.028
  1. ↑ Hoatlin ME, Zhi Y, Ball H, Silvey K, Melnick A, Stone S, Arai S, Hawe N, Owen G, Zelent A, Licht JD. A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF. Blood. 1999 Dec 1;94(11):3737-47. PMID:10572087

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