3lwt

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Revision as of 23:27, 10 April 2013

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Template:STRUCTURE 3lwt

Contents 1 Crystal structure of the Yeast Sac1: Implications for its phosphoinositide phosphatase function 2 Function 3 About this Structure 4 Reference

Crystal structure of the Yeast Sac1: Implications for its phosphoinositide phosphatase function

Template:ABSTRACT PUBMED 20389282

Function

[SAC1_YEAST] Phosphoinositide phosphatase that hydrolyzes PtdIns(3)P and PtdIns(4)P. Has low activity towards PtdIns(3,5)P2. May be involved in the coordination of the activities of the secretory pathway and the actin cytoskeleton.^{[1] [2]}

About this Structure

3lwt is a 1 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

• Manford A, Xia T, Saxena AK, Stefan C, Hu F, Emr SD, Mao Y. Crystal structure of the yeast Sac1: implications for its phosphoinositide phosphatase function. EMBO J. 2010 May 5;29(9):1489-98. Epub 2010 Apr 13. PMID:20389282 doi:10.1038/emboj.2010.57

1. ↑ Hughes WE, Woscholski R, Cooke FT, Patrick RS, Dove SK, McDonald NQ, Parker PJ. SAC1 encodes a regulated lipid phosphoinositide phosphatase, defects in which can be suppressed by the homologous Inp52p and Inp53p phosphatases. J Biol Chem. 2000 Jan 14;275(2):801-8. PMID:10625610
2. ↑ Foti M, Audhya A, Emr SD. Sac1 lipid phosphatase and Stt4 phosphatidylinositol 4-kinase regulate a pool of phosphatidylinositol 4-phosphate that functions in the control of the actin cytoskeleton and vacuole morphology. Mol Biol Cell. 2001 Aug;12(8):2396-411. PMID:11514624