3m65

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Template:STRUCTURE 3m65

Contents

Crystal structure of Bacillus subtilis Lon N-terminal domain

Template:ABSTRACT PUBMED 20600124

Function

[LON1_BACSU] ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity). Has been implicated in preventing sigma(G) activity under non-sporulation conditions.[HAMAP-Rule:MF_01973]

About this Structure

3m65 is a 2 chain structure with sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

  • Duman RE, Lowe J. Crystal structures of Bacillus subtilis Lon protease. J Mol Biol. 2010 Aug 27;401(4):653-70. Epub 2010 Jun 19. PMID:20600124 doi:10.1016/j.jmb.2010.06.030

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OCA

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