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3lwh
From Proteopedia
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{{STRUCTURE_3lwh| PDB=3lwh | SCENE= }} | {{STRUCTURE_3lwh| PDB=3lwh | SCENE= }} | ||
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===Crystal structure of Cren7-dsDNA complex=== | ===Crystal structure of Cren7-dsDNA complex=== | ||
| + | {{ABSTRACT_PUBMED_20345658}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/CREN7_SULSO CREN7_SULSO]] A highly abundant probable chromatin protein, it binds double-strand DNA without sequence specificity; there is approximately 1 Cren7 molecule for 12 bp of DNA. Constrains negative DNA supercoils, increases DNA stability against thermal denaturation. Binding does not require protein methylation. Binds single-strand DNA weakly.<ref>PMID:18096617</ref> | |
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==About this Structure== | ==About this Structure== | ||
| - | + | [[3lwh]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LWH OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:020345658</ref><references group="xtra"/><references/> |
[[Category: Sulfolobus solfataricus]] | [[Category: Sulfolobus solfataricus]] | ||
[[Category: Gong, Y.]] | [[Category: Gong, Y.]] | ||
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[[Category: Methylation]] | [[Category: Methylation]] | ||
[[Category: Protein-dna complex]] | [[Category: Protein-dna complex]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 26 08:33:52 2010'' | ||
Revision as of 23:33, 10 April 2013
Contents |
Crystal structure of Cren7-dsDNA complex
Template:ABSTRACT PUBMED 20345658
Function
[CREN7_SULSO] A highly abundant probable chromatin protein, it binds double-strand DNA without sequence specificity; there is approximately 1 Cren7 molecule for 12 bp of DNA. Constrains negative DNA supercoils, increases DNA stability against thermal denaturation. Binding does not require protein methylation. Binds single-strand DNA weakly.[1]
About this Structure
3lwh is a 3 chain structure with sequence from Sulfolobus solfataricus. Full crystallographic information is available from OCA.
Reference
- Zhang Z, Gong Y, Guo L, Jiang T, Huang L. Structural insights into the interaction of the crenarchaeal chromatin protein Cren7 with DNA. Mol Microbiol. 2010 May;76(3):749-59. Epub 2010 Mar 16. PMID:20345658 doi:10.1111/j.1365-2958.2010.07136.x
- ↑ Guo L, Feng Y, Zhang Z, Yao H, Luo Y, Wang J, Huang L. Biochemical and structural characterization of Cren7, a novel chromatin protein conserved among Crenarchaea. Nucleic Acids Res. 2008 Mar;36(4):1129-37. Epub 2007 Dec 20. PMID:18096617 doi:10.1093/nar/gkm1128
