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3lwh

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Template:STRUCTURE 3lwh

Contents

Crystal structure of Cren7-dsDNA complex

Template:ABSTRACT PUBMED 20345658

Function

[CREN7_SULSO] A highly abundant probable chromatin protein, it binds double-strand DNA without sequence specificity; there is approximately 1 Cren7 molecule for 12 bp of DNA. Constrains negative DNA supercoils, increases DNA stability against thermal denaturation. Binding does not require protein methylation. Binds single-strand DNA weakly.[1]

About this Structure

3lwh is a 3 chain structure with sequence from Sulfolobus solfataricus. Full crystallographic information is available from OCA.

Reference

  • Zhang Z, Gong Y, Guo L, Jiang T, Huang L. Structural insights into the interaction of the crenarchaeal chromatin protein Cren7 with DNA. Mol Microbiol. 2010 May;76(3):749-59. Epub 2010 Mar 16. PMID:20345658 doi:10.1111/j.1365-2958.2010.07136.x
  1. ↑ Guo L, Feng Y, Zhang Z, Yao H, Luo Y, Wang J, Huang L. Biochemical and structural characterization of Cren7, a novel chromatin protein conserved among Crenarchaea. Nucleic Acids Res. 2008 Mar;36(4):1129-37. Epub 2007 Dec 20. PMID:18096617 doi:10.1093/nar/gkm1128

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OCA

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