3m4t
From Proteopedia
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{{STRUCTURE_3m4t| PDB=3m4t | SCENE= }} | {{STRUCTURE_3m4t| PDB=3m4t | SCENE= }} | ||
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===Crystal structure of the BTB domain from Kaiso/ZBTB33, form I=== | ===Crystal structure of the BTB domain from Kaiso/ZBTB33, form I=== | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/KAISO_HUMAN KAISO_HUMAN]] Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3'. Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2.<ref>PMID:11445535</ref> <ref>PMID:14527417</ref> <ref>PMID:15548582</ref> <ref>PMID:15817151</ref> | ||
==About this Structure== | ==About this Structure== | ||
[[3m4t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M4T OCA]. | [[3m4t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M4T OCA]. | ||
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| + | ==Reference== | ||
| + | <references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Chen, L.]] | [[Category: Chen, L.]] | ||
[[Category: Prive, G G.]] | [[Category: Prive, G G.]] | ||
[[Category: Stogios, P J.]] | [[Category: Stogios, P J.]] | ||
| + | [[Category: Activator]] | ||
| + | [[Category: Btb domain]] | ||
| + | [[Category: Btb/poz domain]] | ||
| + | [[Category: Dna-binding]] | ||
| + | [[Category: Kaiso]] | ||
| + | [[Category: Metal-binding]] | ||
| + | [[Category: Nucleus]] | ||
| + | [[Category: Oligomeriation]] | ||
| + | [[Category: Phosphoprotein]] | ||
| + | [[Category: Poz domain]] | ||
| + | [[Category: Protein-protein interaction domain]] | ||
| + | [[Category: Repressor]] | ||
| + | [[Category: Transcription]] | ||
| + | [[Category: Transcription regulation]] | ||
| + | [[Category: Transcriptional regulator kaiso]] | ||
| + | [[Category: Wnt signaling pathway]] | ||
| + | [[Category: Zbtb33]] | ||
| + | [[Category: Zinc finger and btb domain-containing protein 33]] | ||
| + | [[Category: Zinc-finger]] | ||
| + | [[Category: Zinc-finger protein]] | ||
| + | [[Category: Znf348]] | ||
Revision as of 23:34, 10 April 2013
Contents |
Crystal structure of the BTB domain from Kaiso/ZBTB33, form I
Function
[KAISO_HUMAN] Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3'. Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2.[1] [2] [3] [4]
About this Structure
3m4t is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- ↑ Prokhortchouk A, Hendrich B, Jorgensen H, Ruzov A, Wilm M, Georgiev G, Bird A, Prokhortchouk E. The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor. Genes Dev. 2001 Jul 1;15(13):1613-8. PMID:11445535 doi:10.1101/gad.198501
- ↑ Yoon HG, Chan DW, Reynolds AB, Qin J, Wong J. N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso. Mol Cell. 2003 Sep;12(3):723-34. PMID:14527417
- ↑ Ruzov A, Dunican DS, Prokhortchouk A, Pennings S, Stancheva I, Prokhortchouk E, Meehan RR. Kaiso is a genome-wide repressor of transcription that is essential for amphibian development. Development. 2004 Dec;131(24):6185-94. Epub 2004 Nov 17. PMID:15548582 doi:dev.01549
- ↑ Spring CM, Kelly KF, O'Kelly I, Graham M, Crawford HC, Daniel JM. The catenin p120ctn inhibits Kaiso-mediated transcriptional repression of the beta-catenin/TCF target gene matrilysin. Exp Cell Res. 2005 May 1;305(2):253-65. PMID:15817151 doi:S0014-4827(05)00014-5
Categories: Homo sapiens | Chen, L. | Prive, G G. | Stogios, P J. | Activator | Btb domain | Btb/poz domain | Dna-binding | Kaiso | Metal-binding | Nucleus | Oligomeriation | Phosphoprotein | Poz domain | Protein-protein interaction domain | Repressor | Transcription | Transcription regulation | Transcriptional regulator kaiso | Wnt signaling pathway | Zbtb33 | Zinc finger and btb domain-containing protein 33 | Zinc-finger | Zinc-finger protein | Znf348
