1qmh

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[[Image:1qmh.png|left|200px]]
 
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{{STRUCTURE_1qmh| PDB=1qmh | SCENE= }}
{{STRUCTURE_1qmh| PDB=1qmh | SCENE= }}
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===Crystal structure of RNA 3'-terminal phosphate cyclase, an ubiquitous enzyme with unusual topology===
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{{ABSTRACT_PUBMED_10673421}}
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===CRYSTAL STRUCTURE OF RNA 3'-TERMINAL PHOSPHATE CYCLASE, AN UBIQUITOUS ENZYME WITH UNUSUAL TOPOLOGY===
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==Function==
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[[http://www.uniprot.org/uniprot/RTCA_ECOLI RTCA_ECOLI]] Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.<ref>PMID:9738023</ref>
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{{ABSTRACT_PUBMED_10673421}}
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==About this Structure==
==About this Structure==
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[[1qmh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QMH OCA].
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[[1qmh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QMH OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:010673421</ref><ref group="xtra">PMID:015048824</ref><references group="xtra"/>
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<ref group="xtra">PMID:010673421</ref><ref group="xtra">PMID:015048824</ref><references group="xtra"/><references/>
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[[Category: Escherichia coli]]
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[[Category: Escherichia coli k-12]]
[[Category: RNA-3'-phosphate cyclase]]
[[Category: RNA-3'-phosphate cyclase]]
[[Category: Billy, E.]]
[[Category: Billy, E.]]
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[[Category: Wlodawer, A.]]
[[Category: Wlodawer, A.]]
[[Category: 2'3'cyclic phosphate rna]]
[[Category: 2'3'cyclic phosphate rna]]
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[[Category: Rna 3'-terminal phosphate cyclase]]
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[[Category: Ligase]]

Revision as of 19:19, 17 April 2013

Template:STRUCTURE 1qmh

Contents

Crystal structure of RNA 3'-terminal phosphate cyclase, an ubiquitous enzyme with unusual topology

Template:ABSTRACT PUBMED 10673421

Function

[RTCA_ECOLI] Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.[1]

About this Structure

1qmh is a 2 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA.

Reference

  • Palm GJ, Billy E, Filipowicz W, Wlodawer A. Crystal structure of RNA 3'-terminal phosphate cyclase, a ubiquitous enzyme with unusual topology. Structure. 2000 Jan 15;8(1):13-23. PMID:10673421
  • Hicks JM, Hsu VL. The extended left-handed helix: a simple nucleic acid-binding motif. Proteins. 2004 May 1;55(2):330-8. PMID:15048824 doi:10.1002/prot.10630
  1. ↑ Genschik P, Drabikowski K, Filipowicz W. Characterization of the Escherichia coli RNA 3'-terminal phosphate cyclase and its sigma54-regulated operon. J Biol Chem. 1998 Sep 25;273(39):25516-26. PMID:9738023

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