3zn3
From Proteopedia
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{{STRUCTURE_3zn3| PDB=3zn3 | SCENE= }} | {{STRUCTURE_3zn3| PDB=3zn3 | SCENE= }} | ||
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===N-terminal domain of S. pombe Cdc23 APC subunit=== | ===N-terminal domain of S. pombe Cdc23 APC subunit=== | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/APC8_SCHPO APC8_SCHPO]] Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Has a role in promoting metaphase to anaphase transition via the ubiquitination of specific mitotic substrates.<ref>PMID:10526233</ref> | ||
==About this Structure== | ==About this Structure== | ||
[[3zn3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZN3 OCA]. | [[3zn3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZN3 OCA]. | ||
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| + | ==Reference== | ||
| + | <references group="xtra"/><references/> | ||
[[Category: Schizosaccharomyces pombe]] | [[Category: Schizosaccharomyces pombe]] | ||
[[Category: Barford, D.]] | [[Category: Barford, D.]] | ||
Revision as of 19:22, 17 April 2013
Contents |
N-terminal domain of S. pombe Cdc23 APC subunit
Function
[APC8_SCHPO] Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Has a role in promoting metaphase to anaphase transition via the ubiquitination of specific mitotic substrates.[1]
About this Structure
3zn3 is a 1 chain structure with sequence from Schizosaccharomyces pombe. Full crystallographic information is available from OCA.
