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4i9x
From Proteopedia
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{{STRUCTURE_4i9x| PDB=4i9x | SCENE= }} | {{STRUCTURE_4i9x| PDB=4i9x | SCENE= }} | ||
===Crystal structure of human cytomegalovirus glycoprotein UL141 targeting the death receptor TRAIL-R2=== | ===Crystal structure of human cytomegalovirus glycoprotein UL141 targeting the death receptor TRAIL-R2=== | ||
| + | {{ABSTRACT_PUBMED_23555243}} | ||
==Disease== | ==Disease== | ||
Revision as of 19:33, 17 April 2013
Contents |
Crystal structure of human cytomegalovirus glycoprotein UL141 targeting the death receptor TRAIL-R2
Template:ABSTRACT PUBMED 23555243
Disease
[TR10B_HUMAN] Defects in TNFRSF10B may be a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:275355]; also known as squamous cell carcinoma of the head and neck.
Function
[TR10B_HUMAN] Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.[1]
About this Structure
4i9x is a 4 chain structure with sequence from Homo sapiens and Human herpesvirus 5 strain merlin. Full crystallographic information is available from OCA.
Reference
- ↑ Yamaguchi H, Wang HG. CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells. J Biol Chem. 2004 Oct 29;279(44):45495-502. Epub 2004 Aug 18. PMID:15322075 doi:10.1074/jbc.M406933200
