4hy9

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'''Unreleased structure'''
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{{STRUCTURE_4hy9| PDB=4hy9 | SCENE= }}
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===Crystal structure of the substrate binding domain of E.coli DnaK in complex with pyrrhocoricin_LYZZ (residues 1 to 11)===
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{{ABSTRACT_PUBMED_23562829}}
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The entry 4hy9 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/DNAK_ECOLI DNAK_ECOLI]] Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.[HAMAP-Rule:MF_00332] [[http://www.uniprot.org/uniprot/PYRRH_PYRAP PYRRH_PYRAP]] Antibacterial peptide. Affects Gram-negative bacteria E.coli 1106, P.aeruginosa, E.coli D22 and E.cloacae and Gram-positive bacteria M.luteus and B.subtilis.
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Authors: Zahn, M., Straeter, N.
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==About this Structure==
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[[4hy9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HY9 OCA].
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Description: Crystal structure of the substrate binding domain of E.coli DnaK in complex with pyrrhocoricin(1-11)_LYZZ
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[[Category: Escherichia coli k-12]]
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[[Category: Straeter, N.]]
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[[Category: Zahn, M.]]
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[[Category: Antimicrobial peptide]]
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[[Category: Chaperone]]
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[[Category: Peptide binding protein]]

Revision as of 20:22, 17 April 2013

Template:STRUCTURE 4hy9

Crystal structure of the substrate binding domain of E.coli DnaK in complex with pyrrhocoricin_LYZZ (residues 1 to 11)

Template:ABSTRACT PUBMED 23562829

Function

[DNAK_ECOLI] Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.[HAMAP-Rule:MF_00332] [PYRRH_PYRAP] Antibacterial peptide. Affects Gram-negative bacteria E.coli 1106, P.aeruginosa, E.coli D22 and E.cloacae and Gram-positive bacteria M.luteus and B.subtilis.

About this Structure

4hy9 is a 4 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA.

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