2erf

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /> <applet load="2erf" size="450" color="white" frame="true" align="right" spinBox="true" caption="2erf, resolution 1.45&Aring;" /> '''Crystal Structure o...)
Line 1: Line 1:
-
[[Image:2erf.gif|left|200px]]<br />
+
[[Image:2erf.gif|left|200px]]<br /><applet load="2erf" size="350" color="white" frame="true" align="right" spinBox="true"
-
<applet load="2erf" size="450" color="white" frame="true" align="right" spinBox="true"
+
caption="2erf, resolution 1.45&Aring;" />
caption="2erf, resolution 1.45&Aring;" />
'''Crystal Structure of the Thrombospondin-1 N-terminal Domain at 1.45A Resolution'''<br />
'''Crystal Structure of the Thrombospondin-1 N-terminal Domain at 1.45A Resolution'''<br />
==Overview==
==Overview==
-
The N-terminal domain of thrombospondin-1 (TSPN-1) mediates the protein's, interaction with (1) glycosaminoglycans, calreticulin, and integrins, during cellular adhesion, (2) low-density lipoprotein receptor-related, protein during uptake and clearance, and (3) fibrinogen during platelet, aggregation. The crystal structure of TSPN-1 to 1.8 A resolution is a beta, sandwich with 13 antiparallel beta strands and 1 irregular strand-like, segment. Unique structural features of the N- and C-terminal regions, and, the disulfide bond location, distinguish TSPN-1 from the laminin G domain, and other concanavalin A-like lectins/glucanases superfamily members. The, crystal structure of the complex of TSPN-1 with heparin indicates that, residues R29, R42, and R77 in an extensive positively charged patch at the, bottom of the domain specifically associate with the sulfate groups of, heparin. The TSPN-1 structure and identified adjacent linker region, provide a structural framework for the analysis of the TSPN domain of, various molecules, including TSPs, NELLs, many collagens, TSPEAR, and, kielin.
+
The N-terminal domain of thrombospondin-1 (TSPN-1) mediates the protein's interaction with (1) glycosaminoglycans, calreticulin, and integrins during cellular adhesion, (2) low-density lipoprotein receptor-related protein during uptake and clearance, and (3) fibrinogen during platelet aggregation. The crystal structure of TSPN-1 to 1.8 A resolution is a beta sandwich with 13 antiparallel beta strands and 1 irregular strand-like segment. Unique structural features of the N- and C-terminal regions, and the disulfide bond location, distinguish TSPN-1 from the laminin G domain and other concanavalin A-like lectins/glucanases superfamily members. The crystal structure of the complex of TSPN-1 with heparin indicates that residues R29, R42, and R77 in an extensive positively charged patch at the bottom of the domain specifically associate with the sulfate groups of heparin. The TSPN-1 structure and identified adjacent linker region provide a structural framework for the analysis of the TSPN domain of various molecules, including TSPs, NELLs, many collagens, TSPEAR, and kielin.
==Disease==
==Disease==
Line 11: Line 10:
==About this Structure==
==About this Structure==
-
2ERF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2ERF OCA].
+
2ERF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERF OCA].
==Reference==
==Reference==
Line 25: Line 24:
[[Category: tsp-1]]
[[Category: tsp-1]]
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 21:54:32 2007''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:13:52 2008''

Revision as of 15:13, 21 February 2008

Image:2erf.gif

2erf, resolution 1.45Å

Drag the structure with the mouse to rotate

Crystal Structure of the Thrombospondin-1 N-terminal Domain at 1.45A Resolution

Contents

Overview

The N-terminal domain of thrombospondin-1 (TSPN-1) mediates the protein's interaction with (1) glycosaminoglycans, calreticulin, and integrins during cellular adhesion, (2) low-density lipoprotein receptor-related protein during uptake and clearance, and (3) fibrinogen during platelet aggregation. The crystal structure of TSPN-1 to 1.8 A resolution is a beta sandwich with 13 antiparallel beta strands and 1 irregular strand-like segment. Unique structural features of the N- and C-terminal regions, and the disulfide bond location, distinguish TSPN-1 from the laminin G domain and other concanavalin A-like lectins/glucanases superfamily members. The crystal structure of the complex of TSPN-1 with heparin indicates that residues R29, R42, and R77 in an extensive positively charged patch at the bottom of the domain specifically associate with the sulfate groups of heparin. The TSPN-1 structure and identified adjacent linker region provide a structural framework for the analysis of the TSPN domain of various molecules, including TSPs, NELLs, many collagens, TSPEAR, and kielin.

Disease

Known disease associated with this structure: Sudden infant death with dysgenesis of the testes syndrome OMIM:[604714]

About this Structure

2ERF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structures of the thrombospondin-1 N-terminal domain and its complex with a synthetic pentameric heparin., Tan K, Duquette M, Liu JH, Zhang R, Joachimiak A, Wang JH, Lawler J, Structure. 2006 Jan;14(1):33-42. PMID:16407063

Page seeded by OCA on Thu Feb 21 17:13:52 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2erf"
Personal tools